New Advances in Proteomics in Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 April 2025 | Viewed by 3695
Special Issue Editor
Interests: patch-clamp on neuroblastoma cell line with PFAS agents on GABA_A receptors; morphological and physiological alterations on rat testis and pancreas upon exposure to hypergravity; proteomics and metabolomics of monocytes exposed to inflammatory cytokines
Special Issue Information
Dear Colleagues,
During the last thirty years, proteomics has proved to be a powerful tool to define the metabolic pathways and cellular mechanisms involved in the pathogenesis and development of human diseases. Besides the investigation of potential causes, the current interest in proteomics aims to identify new protein molecules as potential biomarkers, making proteomics a powerful prognostic and early diagnostic tool. Proteomics analysis enable the characterization of disease-associated proteins, their possible modifications, and reciprocal interactions contributing to understanding of human illnesses, including cancer, infectious, and autoimmune diseases. By comparing different protein profiles between healthy and sick individuals, it is possible to identify differentially expressed proteins which can change in pathological conditions, not only at single cell or tissue level, but also in intracellular organelles and body fluids. The different expression level can allow the fast detection of a disease, monitor its temporal course, and speed up the development of therapeutical agents, revealing altered cell signaling pathways and gaining insights into altered molecular interactions behind disease pathogenesis. Together with the discovery of new therapeutical agents, proteomics can lead to a personalized medicine tracing the patient profile, their probability of getting sick, and specific treatment strategies for specific patient populations. This Special Issue aims to focus on the molecular mechanisms of pathogenesis in order to identify specific pathways involved in diseases and proteins useful for fast and precise disease detection.
Dr. Valeria Magnelli
Guest Editor
Manuscript Submission Information
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Keywords
- proteomics
- protein
- profile
- molecular mechanism
- biomarker
- therapeutical agent
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