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New Advances in Research on Alzheimer’s Disease: 2nd Edition
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New Advances in Research on Alzheimer’s Disease: 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 20 June 2025 | Viewed by 2497

Special Issue Editors

Dr. Stella Gagliardi

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Guest Editor
IRCCS Mondino Fondation Genomic and Post Genomic Unit, 27100 Pavia, PV, Italy
Interests: coding and non coding RNA; gene expression; neurodegenerative diseases; genetic
Special Issues, Collections and Topics in MDPI journals
Dr. Carlo Morasso

E-Mail
Guest Editor
Istituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, Italy
Interests: biomedical spectroscopy; clinical spectroscopy; Alzheimer’s disease; breast cancer; nanomedicine; Raman spectroscopy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Alzheimer’s disease (AD) is considered the most common cause of dementia and is an incurable, progressive neurodegenerative disorder. To date, novel disease-modifying therapies have been shown to provide significant benefits to patients who suffer from this devastating disorder.

Moreover, preventive approaches of this pathology that are based on genetic predisposition, senolytic approaches, diet, or intellectual activity are increasingly relevant.

The aim of this Special Issue is to provide (but is not limited to) an overview of the recent advances in the field of novel therapy and targets for Alzheimer’s disease. In addition, data about preventive approaches are welcomed.

We invite researchers to submit original papers and reviews about the discovery of new targets and novel therapies for Alzheimer’s disease. Papers about other types of dementia will also be accepted.

Dr. Stella Gagliardi
Dr. Carlo Morasso
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • therapy
  • prevention
  • new molecules
  • Alzheimer’s disease
  • genetics
  • nanoformulation
  • targets
  • dementia
  • biomarker discovery

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Published Papers (2 papers)

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45 pages, 4558 KiB  
Review
The Role of Genetic, Environmental, and Dietary Factors in Alzheimer’s Disease: A Narrative Review
by Beyza Mertaş and İ. İpek Boşgelmez
Int. J. Mol. Sci. 2025, 26(3), 1222; https://doi.org/10.3390/ijms26031222 - 30 Jan 2025
Viewed by 481
Abstract
Alzheimer’s disease (AD) is one of the most common and severe forms of dementia and neurodegenerative disease. As life expectancy increases in line with developments in medicine, the elderly population is projected to increase in the next few decades; therefore, an increase in [...] Read more.
Alzheimer’s disease (AD) is one of the most common and severe forms of dementia and neurodegenerative disease. As life expectancy increases in line with developments in medicine, the elderly population is projected to increase in the next few decades; therefore, an increase in the prevalence of some diseases, such as AD, is also expected. As a result, until a radical treatment becomes available, AD is expected to be more frequently recorded as one of the top causes of death worldwide. Given the current lack of a cure for AD, and the only treatments available being ones that alleviate major symptoms, the identification of contributing factors that influence disease incidence is crucial. In this context, genetic and/or epigenetic factors, mainly environmental, disease-related, dietary, or combinations/interactions of these factors, are assessed. In this review, we conducted a literature search focusing on environmental factors such as air pollution, toxic elements, pesticides, and infectious agents, as well as dietary factors including various diets, vitamin D deficiency, social factors (e.g., tobacco and alcohol use), and variables that are affected by both environmental and genetic factors, such as dietary behavior and gut microbiota. We also evaluated studies on the beneficial effects of antibiotics and diets, such as the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) and Mediterranean diets. Full article
(This article belongs to the Special Issue New Advances in Research on Alzheimer’s Disease: 2nd Edition)
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8 pages, 229 KiB  
Perspective
Therapeutic Challenges Derived from the Interaction Among Apolipoprotein E, Cholesterol, and Amyloid in Alzheimer’s Disease
by Manuel Menendez-Gonzalez
Int. J. Mol. Sci. 2024, 25(22), 12029; https://doi.org/10.3390/ijms252212029 - 8 Nov 2024
Viewed by 1662
Abstract
The isoform E4 of the Apolipoprotein E (ApoE) represents one of the strongest genetic risk factors for late-onset Alzheimer’s disease (AD). ApoE has key roles in cholesterol transport and amyloid-β (Aβ) metabolism, which are both central to AD pathogenesis. The E4 isoform has [...] Read more.
The isoform E4 of the Apolipoprotein E (ApoE) represents one of the strongest genetic risk factors for late-onset Alzheimer’s disease (AD). ApoE has key roles in cholesterol transport and amyloid-β (Aβ) metabolism, which are both central to AD pathogenesis. The E4 isoform has been implicated in reduced cholesterol homeostasis, increased Aβ aggregation, and heightened tau phosphorylation, contributing to amyloid plaques and neurodegeneration. This manuscript examines the complex interactions among ApoE isoforms, cholesterol metabolism, and amyloid pathology. Moreover, the therapeutic challenges associated with lipid-lowering agents (e.g., statins, PCSK9 inhibitors), anti-amyloid immunotherapies, and anticoagulants are described, focusing on ApoE4 carriers. Decision-making challenges are discussed by analyzing the pros and cons of these therapies. Full article
(This article belongs to the Special Issue New Advances in Research on Alzheimer’s Disease: 2nd Edition)
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