Mechanisms in Aquatic Toxicology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".
Deadline for manuscript submissions: closed (30 September 2019) | Viewed by 7994
Special Issue Editor
Interests: aquatic toxicology; systems biology; developmental biology; endocrine disruption; stress physiology; embryonic development; zebrafish; alternative testing approaches; adverse outcome pathways
Special Issue Information
Dear Colleagues,
Aquatic toxicologists are faced with the daunting task of generating, understanding, predicting and applying scientific data on the potential adverse effects of a rapidly increasing number of chemicals in the aquatic environment. Molecular technologies have enabled the development of systems biology approaches allowing us to describe the underlying toxicological mechanisms to an incredible level of detail. Simultaneously, conceptual frameworks for organizing and structuring toxicological information—most notably the adverse outcome pathway framework—are currently being adopted worldwide, facilitating real-life decision making processes by identifying causal linkages between mechanistic data and biological endpoints that are relevant to risk assessment. This convergence of high-quality, data-rich fundamental science with tractable and transparent application strategies provides a strong basis for facing the complex toxicological challenges of 21st century society. This Special Issue aims to advance our understanding of the impact of toxicants on aquatic organisms and ecosystems, and to contribute to the development of new approaches and applications in aquatic toxicology. We welcome manuscripts that focus on any of these areas, from the fundamental understanding of toxicological mechanisms to computational prediction and regulatory applications of mechanistic aquatic toxicity data.
Prof. Dr. Dries Knapen
Guest Editor
Manuscript Submission Information
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Keywords
- aquatic toxicology
- molecular mechanisms
- toxicokinetics
- model organisms
- systems biology
- adverse outcome pathways
- alternative testing approaches
- cross-species extrapolation
- computational toxicology
- hazard and risk assessment
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