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Pathogenesis of Pregnancy-Related Complication (5th Edition)
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Pathogenesis of Pregnancy-Related Complication (5th Edition)

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 February 2025 | Viewed by 2473

Special Issue Editor

Prof. Dr. Ilona Hromadnikova

E-Mail Website
Guest Editor
Head, Department of Molecular Biology and Cell Pathology, Third Faculty of Medicine, Charles University, Prague, Czech Republic
Interests: pregnancy-related complications; pathogenesis; diagnosis/prognosis biomarkers; epigenetics; extracellular nucleic acids in maternal circulation; postpartum/postnatal short-term and long-term consequences
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Preeclampsia, HELLP syndrome, fetal growth restriction, gestational diabetes mellitus, preterm birth (preterm prelabor rupture of membranes and spontaneous preterm labor), and an invasive placenta are major complications responsible for maternal and perinatal morbidity and mortality. The elucidation of the pathogenetic mechanisms related to the initiation and onset of severe pregnancy-related complications enables the identification of potential biomarkers for the early stratification of at-risk patients. Additionally, pregnancy-related complications induce long-term metabolic and vascular abnormalities that might increase the overall risk of metabolic, cardiovascular, cerebrovascular, kidney, and other diseases later in life in mothers and their offspring. This Special Issue aims to provide an overview of the latest research on the mechanisms associated with pregnancy-related complications as well as of the contributions of pregnancy-related complications to the later development of various diseases. This will include the underlying mechanisms, diagnostics/prognostics, and treatment strategies associated with pregnancy-related complications, and will be of interest to scientists as well as clinicians working in this quickly expanding area.

Topics may include (but are not limited to) the following:

  • Pathogenesis of pregnancy-related complications;
  • Diagnosis and prognosis of pregnancy-related complications;
  • Short-term and long-term follow-up after pregnancy-related complications (mothers and offspring);
  • Novel treatment modalities of pregnancy-related complications and their short-term as well as long-term consequences.

Prof. Dr. Ilona Hromadnikova
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gestational hypertension
  • preeclampsia
  • HELLP syndrome
  • fetal growth restriction
  • gestational diabetes mellitus
  • preterm birth
  • invasive placenta

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Published Papers (3 papers)

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Research

18 pages, 1326 KiB  
Article
The Impact of Gestational Diabetes Mellitus on Minipuberty in Girls
by Karolina Kowalcze, Sofia Burgio, Giuseppe Gullo, Joanna Kula-Gradzik, Johannes Ott and Robert Krysiak
Int. J. Mol. Sci. 2024, 25(21), 11766; https://doi.org/10.3390/ijms252111766 - 1 Nov 2024
Viewed by 589
Abstract
Minipuberty is the second phase of physiological activation of the reproductive axis, playing a role in the postnatal development of sexual organs. The course of female minipuberty was found to be affected by low maternal vitamin D status and hypothyroidism during pregnancy. The [...] Read more.
Minipuberty is the second phase of physiological activation of the reproductive axis, playing a role in the postnatal development of sexual organs. The course of female minipuberty was found to be affected by low maternal vitamin D status and hypothyroidism during pregnancy. The aim of the current study was to assess the hormonal profile and the size of sexual organs in daughters of mothers with gestational diabetes mellitus. The study included three matched groups of infant girls: daughters of healthy women without metabolic disorders during pregnancy (group 1), daughters of women with poorly controlled gestational diabetes mellitus (group 2), and daughters of women with gestational diabetes mellitus adequately controlled during pregnancy (group 3). Urinary levels of gonadotropins, salivary levels of estradiol, testosterone, DHEA-S and progesterone, ovarian volume, uterine length and breast diameter were measured from postnatal month 1 to postnatal month 18. Concentrations of FSH, LH and estradiol were higher, while concentration of progesterone was lower in group 2 than in the remaining groups. There were no between-group differences in concentrations of testosterone and DHEA-S. Levels of LH, FSH, estradiol and progesterone correlated with maternal whole-blood levels of glycated hemoglobin. Group 2 was also characterized by the longest detection periods for LH and estradiol. Ovarian volume, uterine length and breast diameter were greater in group 1 than in the remaining two groups. Over the entire observation period, there were no differences in hormone levels and sizes of the sexual organs between groups 1 and 3. The obtained results suggest that poorly controlled, but not well controlled, gestational diabetes mellitus affects the course of female minipuberty. Full article
(This article belongs to the Special Issue Pathogenesis of Pregnancy-Related Complication (5th Edition))
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17 pages, 902 KiB  
Article
Pilot Study on the Effect of Patient Condition and Clinical Parameters on Hypoxia-Induced Factor Expression: HIF1A, EPAS1 and HIF3A in Human Colostrum Cells
by Julia Zarychta, Adrian Kowalczyk, Karolina Słowik, Dominika Przywara, Alicja Petniak, Adrianna Kondracka, Monika Wójtowicz-Marzec, Patrycja Słyk-Gulewska, Anna Kwaśniewska, Janusz Kocki and Paulina Gil-Kulik
Int. J. Mol. Sci. 2024, 25(20), 11042; https://doi.org/10.3390/ijms252011042 - 14 Oct 2024
Viewed by 790
Abstract
Hypoxia-inducible factor 1 (HIF-1) may play a role in mammary gland development, milk production and secretion in mammals. Due to the limited number of scientific reports on the expression of HIF genes in colostrum cells, it was decided to examine the expression of [...] Read more.
Hypoxia-inducible factor 1 (HIF-1) may play a role in mammary gland development, milk production and secretion in mammals. Due to the limited number of scientific reports on the expression of HIF genes in colostrum cells, it was decided to examine the expression of HIF1A, HIF3A and EPAS1 in the these cells, collected from 35 patients who voluntarily agreed to provide their biological material for research, were informed about the purpose of the study and signed a consent to participate in it. The expression of HIF genes was assessed using qPCR. Additionally, the influence of clinical parameters (method of delivery, occurrence of stillbirths in previous pregnancies, BMI level before pregnancy and at the moment of delivery, presence of hypertension during pregnancy, presence of Escherichia coli in vaginal culture, iron supplement and heparin intake during pregnancy) on the gene expression was assessed, revealing statistically significant correlations. The expression of HIF1A was 3.5-fold higher in the case of patients with the presence of E. coli in vaginal culture (p = 0.041) and 2.5 times higher (p = 0.031) in samples from women who used heparin during pregnancy. Approximately 1.7-fold higher expression of the EPAS1 was observed in women who did not supplement iron during pregnancy (p = 0.046). To our knowledge, these are the first studies showing the relationship between HIF expression in cells from breast milk and the method of delivery and health condition of women giving birth. The assessment of HIF expression requires deeper examination in a larger study group, and the results of further studies will allow to determine whether HIF can become biomarkers in pregnancy pathology states. Full article
(This article belongs to the Special Issue Pathogenesis of Pregnancy-Related Complication (5th Edition))
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12 pages, 1135 KiB  
Article
Differences in DNA Methylation in Genes Involved in Vitamin D Metabolism Are Related to Insulin Requirement in Pregnant Women with Gestational Diabetes Mellitus
by Nerea Peña-Montero, Teresa María Linares-Pineda, Andrea Fernández-Valero, Fuensanta Lima-Rubio, Ana María Fernández-Ramos, Carolina Gutiérrez-Repiso, María Suárez-Arana, María José Picón-César, María Molina-Vega and Sonsoles Morcillo
Int. J. Mol. Sci. 2024, 25(19), 10576; https://doi.org/10.3390/ijms251910576 - 1 Oct 2024
Viewed by 694
Abstract
In a previous study performed by our group, pregnant women with Gestational Diabetes (GDM) showed higher vitamin D (VitD) levels in the last trimester, particularly in those requiring insulin. This phenomenon was not linked to factors like season or supplementation. This study aimed [...] Read more.
In a previous study performed by our group, pregnant women with Gestational Diabetes (GDM) showed higher vitamin D (VitD) levels in the last trimester, particularly in those requiring insulin. This phenomenon was not linked to factors like season or supplementation. This study aimed to investigate if insulin treatment in GDM affects DNA methylation in VitD metabolism genes. Thirty-two pregnant women were selected, half of whom had GDM, and were divided into insulin-treated and lifestyle groups. The DNA methylation levels in CpGs from 47 VitD metabolism-related genes were analyzed at the diagnostic visit (24–28 weeks) and before delivery. At week 36–38 of pregnancy, twenty-six CpG sites were differentially methylated (DMPs) in the insulin-treated group compared with the control group and the lifestyle group. Twenty-two of these DMPs were not different at the diagnostic visit. Six CpGs (cg18276810 (CTNNB1), cg03919554 (FGFR3), cg03984919 (NCOA1), cg19218509 (ASIP), cg09922639 (SMAD3), and cg25356935 (PDZD3)) showed significant correlations with VitD levels, not only before childbirth, but also in the postpartum period and at one year later. This suggests that insulin treatment in GDM could influence DNA methylation in genes involved in vitamin D metabolism, affecting VitD levels during and after pregnancy. Further research is warranted to elucidate these findings’ clinical implications. Full article
(This article belongs to the Special Issue Pathogenesis of Pregnancy-Related Complication (5th Edition))
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