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Molecular Therapeutic Strategies in Allergic Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 588

Special Issue Editor

Special Issue Information

Dear Colleagues,

In this Special Issue of the International Journal of Molecular Sciences, we focus on the latest advancements in allergen identification and innovative strategies for managing their impact on human health. This Special Issue covers topics related to environmental allergens, food allergies, the influence of pollution on allergic reactions, and new allergens in the context of the opportunities offered by modern allergy diagnostics, including Molecular Allergy Diagnostics (MDA).

The significance of MDA lies in its ability to pinpoint specific allergens responsible for adverse reactions. By identifying these allergens at a molecular level, precise and personalized treatment options can be offered, tailored to each individual’s sensitivities. This targeted approach shortens diagnostic time and improves treatment outcomes for patients, enabling the avoidance of specific triggers and thus reducing the risk of allergic reactions. One of the methods for treating allergic diseases is Allergen Immunotherapy (AIT). Molecular diagnostic methods in allergy, by providing precise allergen identification, assist in selecting the appropriate allergens for AIT and in qualifying patients with the highest likelihood of success with this therapy. In cases of food allergies, effective therapy may not always be feasible, and the complete elimination of allergens from our surroundings may be challenging. Therefore, the identification and understanding of allergens triggering allergic reactions, as well as those causing cross-reactivity, along with new and unexpected sources of allergens, are of crucial importance. Hence, MDA is particularly important for individuals susceptible to anaphylactic shock.

The exploration of new allergens, cross-reactivity patterns, and unexpected sources of allergens presents continual challenges in the treatment of allergies. Ongoing research and monitoring in MDA are essential for identifying emerging allergens, understanding cross-reactivity mechanisms, and uncovering hidden allergen sources. By remaining vigilant and responsive to these evolving trends, healthcare professionals can adapt diagnostic strategies, raise awareness, and improve treatment outcomes for individuals affected by allergies through a molecular lens.

By utilizing MDA, doctors can expedite the diagnostic process, improve patient care, and optimize treatment outcomes for allergic diseases. Collaborators interested in advancing knowledge in this area are encouraged to join this innovative initiative.

This Special Issue is supervised by Dr. Sylwia Smolińska and assisted by our Topical Advisory Panel Member Dr. Emilia Majsiak (Department of Health Promotion, Chair of Nursing Development, Faculty Health of Sciences, Medical University of Lublin).

Dr. Sylwia Smolińska
Guest Editor

Manuscript Submission Information

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Keywords

  • molecular allergy diagnostics
  • allergen identification
  • allergen neutralization/elimination strategies
  • allergen immunotherapy
  • impact of pollution on allergies
  • new allergens
  • cross-reactivity
  • unexpected allergen sources

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Published Papers (1 paper)

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Research

11 pages, 3728 KiB  
Article
Extracellular ATP Contributes to Barrier Function and Inflammation in Atopic Dermatitis: Potential for Topical Treatment of Atopic Dermatitis by Targeting Extracellular ATP
by Kazuhiko Yamamura, Fumitaka Ohno, Shu Yotsumoto, Yuki Sato, Nanae Kimura, Kiichiro Nishio, Keiichi Inoue, Toshio Ichiki, Yoko Kuba-Fuyuno, Kei Fujishima, Takamichi Ito, Makiko Kido-Nakahara, Gaku Tsuji and Takeshi Nakahara
Int. J. Mol. Sci. 2024, 25(22), 12294; https://doi.org/10.3390/ijms252212294 - 15 Nov 2024
Viewed by 389
Abstract
Atopic dermatitis (AD) is characterized by chronic inflammation, barrier dysfunction, and pruritus, exacerbated by external stimuli, such as scratching. This study investigates the role of extracellular adenosine triphosphate (ATP) in the pathophysiology of AD and assesses the therapeutic potential of clodronate, an ATP [...] Read more.
Atopic dermatitis (AD) is characterized by chronic inflammation, barrier dysfunction, and pruritus, exacerbated by external stimuli, such as scratching. This study investigates the role of extracellular adenosine triphosphate (ATP) in the pathophysiology of AD and assesses the therapeutic potential of clodronate, an ATP release inhibitor. Our research demonstrates that extracellular ATP impairs skin barrier function by reducing the filaggrin expression in the keratinocytes, a critical protein for barrier integrity. Furthermore, ATP release, triggered by IL-4 and mechanical stimuli, amplifies inflammation by promoting cytokine and chemokine production by the immune cells. Clodronate, by inhibiting ATP release, restores the filaggrin levels in the keratinocytes, reduces TARC production in the dendritic cells, and alleviates AD symptoms in a mouse model. These findings suggest that targeting extracellular ATP could offer a novel therapeutic approach to improving skin barrier function and reducing inflammation in AD. Future studies should explore the long-term efficacy and safety of ATP-targeted therapies in clinical settings. Full article
(This article belongs to the Special Issue Molecular Therapeutic Strategies in Allergic Diseases)
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