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Brain Neurotransmitters in Genetic Control of Behavior 2.0
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Brain Neurotransmitters in Genetic Control of Behavior 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 29264

Special Issue Editor

Prof. Dr. Nina K. Popova

E-Mail Website
Guest Editor
Department of Behavioral Neurogenomics, Institute of Cytology and Genetics, Lavrentyeva av. 10, Novosibirsk 630090, Russia
Interests: brain neurotransmitters; behavior; brain serotonin system; neurotrophic factors; aggression; depression
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

A Special Issue entitled “Brain Neurotransmitters in Genetic Control of Behavior" is being prepared for the IJMS journal. Brain neurotransmitters are playing crucial roles in the mechanisms of brain and behavioral plasticity. Enzymes, transporters and receptors of brain neurotransmitters are under the control of various genetic and epigenetic factors. Moreover, the majority of proteins could undergo different posttranslational modifications that significantly affect their function.

This Special Issue focuses on the role of brain neurotransmitters in the regulation of normal and pathological behavior as well as genetic predisposition to behavioral disorders. We warmly welcome submissions, including original papers and reviews dealing with different aspects of neurotransmitters contribution in behavioral control.

Prof. Dr. Nina K. Popova
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • behavioral neurogenomics
  • neuroplasticity
  • brain neurotransmitters
  • normal and pathological behavior
  • neurodegenerative diseases
  • gene and protein expression
  • posttranslational regulation
  • microRNA in behavioral control

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Published Papers (2 papers)

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Review

27 pages, 2482 KiB  
Review
The Implication of 5-HT Receptor Family Members in Aggression, Depression and Suicide: Similarity and Difference
by Nina K. Popova, Anton S. Tsybko and Vladimir S. Naumenko
Int. J. Mol. Sci. 2022, 23(15), 8814; https://doi.org/10.3390/ijms23158814 - 8 Aug 2022
Cited by 33 | Viewed by 7762
Abstract
Being different multifactorial forms of psychopathology, aggression, depression and suicidal behavior, which is considered to be violent aggression directed against the self, have principal neurobiological links: preclinical and clinical evidence associates depression, aggression and suicidal behavior with dysregulation in central serotonergic (5-HT) neurotransmission. [...] Read more.
Being different multifactorial forms of psychopathology, aggression, depression and suicidal behavior, which is considered to be violent aggression directed against the self, have principal neurobiological links: preclinical and clinical evidence associates depression, aggression and suicidal behavior with dysregulation in central serotonergic (5-HT) neurotransmission. The implication of different types of 5-HT receptors in the genetic and epigenetic mechanisms of aggression, depression and suicidality has been well recognized. In this review, we consider and compare the orchestra of 5-HT receptors involved in these severe psychopathologies. Specifically, it concentrates on the role of 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3 and 5-HT7 receptors in the mechanisms underlying the predisposition to aggression, depression and suicidal behavior. The review provides converging lines of evidence that: (1) depression-related 5-HT receptors include those receptors with pro-depressive properties (5-HT2A, 5-HT3 and 5-HT7) as well as those providing an antidepressant effect (5-HT1A, 5-HT1B, 5-HT2C subtypes). (2) Aggression-related 5-HT receptors are identical to depression-related 5-HT receptors with the exception of 5-HT7 receptors. Activation of 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C receptors attenuate aggressiveness, whereas agonists of 5-HT3 intensify aggressive behavior. Full article
(This article belongs to the Special Issue Brain Neurotransmitters in Genetic Control of Behavior 2.0)
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24 pages, 1831 KiB  
Review
Neurotransmitters—Key Factors in Neurological and Neurodegenerative Disorders of the Central Nervous System
by Raluca Ioana Teleanu, Adelina-Gabriela Niculescu, Eugenia Roza, Oana Vladâcenco, Alexandru Mihai Grumezescu and Daniel Mihai Teleanu
Int. J. Mol. Sci. 2022, 23(11), 5954; https://doi.org/10.3390/ijms23115954 - 25 May 2022
Cited by 117 | Viewed by 20972
Abstract
Neurotransmitters are molecules that amplify, transmit, and convert signals in cells, having an essential role in information transmission throughout the nervous system. Hundreds of such chemicals have been discovered in the last century, continuing to be identified and studied concerning their action on [...] Read more.
Neurotransmitters are molecules that amplify, transmit, and convert signals in cells, having an essential role in information transmission throughout the nervous system. Hundreds of such chemicals have been discovered in the last century, continuing to be identified and studied concerning their action on brain health. These substances have been observed to influence numerous functions, including emotions, thoughts, memories, learning, and movements. Thus, disturbances in neurotransmitters’ homeostasis started being correlated with a plethora of neurological and neurodegenerative disorders. In this respect, the present paper aims to describe the most important neurotransmitters, broadly classified into canonical (e.g., amino acids, monoamines, acetylcholine, purines, soluble gases, neuropeptides) and noncanonical neurotransmitters (e.g., exosomes, steroids, D-aspartic acid), and explain their link with some of the most relevant neurological conditions. Moreover, a brief overview of the recently developed neurotransmitters’ detection methods is offered, followed by several considerations on the modulation of these substances towards restoring homeostasis. Full article
(This article belongs to the Special Issue Brain Neurotransmitters in Genetic Control of Behavior 2.0)
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