Recent Advances in B Cells: Signal Transduction and Therapeutic Potential
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 2513
Special Issue Editor
Interests: regulation of the immune response; B cells; signaling; receptor cross-talk; regulatory cells; autoimmunity; rheumatoid arthritis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
B cells play a critical role in the development of effective immune response; they differentiate into plasma cells or memory B cells, secrete high affinity antibodies and a variety of cytokines, provide long-lasting memory, present antigens to T cells and regulate immune responses. However, B cells can also cause diseases through recognizing and reacting to self. B cells must be educated to differentiate self from non-self; thus, they go through several developmental checkpoints where self-specific cells are eliminated. These checkpoints are under the control of B cell receptor (BCR) mediated signals, but also influenced by Toll-like receptor 7 (TLR-7) and TLR-9, the innate immune sensors. BCR, TLR-7, TLR-9 and possibly other receptors function together to regulate the pathogenesis of autoimmunity.
Dysregulated B cell signaling can be the primary driver of many human autoimmune diseases. Studying signaling and co-signaling molecules and pathways in B cells would help to elucidate the molecular mechanisms of autoimmune diseases and would lead to the discovery of novel therapeutic targets and to the development of new drugs for the treatment of autoimmune diseases.
This Special Issue, “Recent Advances in B Cells: Signal Transduction and Therapeutic Potential” in the International Journal of Molecular Sciences will comprise a selection of research papers and reviews that will contribute to defining proteins and signaling pathways that support atypical B cell response in autoimmune diseases. This will also help researchers to better understand disease mechanisms, to identify key immune regulatory processes, and eventually, provide new ideas for precision therapy.
Prof. Dr. Gabriella Sármay
Guest Editor
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Keywords
- Anergy
- Autoimmune diseases
- B cell signaling
- Central tolerance
- Extrafollicular response
- Germinal center
- Immune regulation
- Peripheral tolerance
- Signaling pathways and molecules
- Toll-like receptors
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