Quality Control of Mitochondria: Protection against Bone Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Role of Xenobiotics".
Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 2603
Special Issue Editor
Interests: osteoclasts; osteoblasts; osteocytes; mitochondrial quality control; osteoporosis; aging; cellular senescence; oxidative stress
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
A balance between the function of bone-resorbing osteoclasts and bone-building osteoblasts is essential for bone homeostasis. However, pathological or physiological changes, such as IRE, inflammation, or aging, lead to increased osteoclast numbers and decreased osteoblast numbers, tilting the balance in favor of bone resorption and eventually causing bone diseases. Thus, understanding the cellular and molecular mechanisms involved in the differentiation of the two types of bone cells is important for the development of novel therapies.
Mitochondria are dynamic organelles whose structure is constantly changing via several processes that include fusion and fission of the tubular mitochondrial network, mitochondrial biogenesis, and elimination of unwanted mitochondria by mitophagy (mitochondrial specific autophagy). Maintaining a healthy mitochondria network is vital for fatty acid oxidation, oxidative phosphorylation (OxPhos), and energy production, among many other metabolic functions. OxPhos produces mitochondrial ROS as byproducts, which can be important signaling molecules but, when produced in excess, damage cells and contribute to disease and aging.
We invite researchers to submit original research and review articles covering significant developments in the mitochondrial function and oxidative stress of bone cells, as well as novel medicines or strategies that hold promise in the prevention and/or treatment of skeletal diseases. In particular, we welcome research covering novel molecular mechanisms, new tools on bone research, or any animal studies with clinical relevance.
Dr. Ha-Neui Kim
Guest Editor
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Keywords
- Osteoclast
- Osteoblast
- osteocyte
- chondrocyte
- ROS
- mitochondria
- skeletal diseases
- aging
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