The Roles of Ion Channels and Transporters in Intracellular Signaling
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (10 July 2023) | Viewed by 6698
Special Issue Editors
Interests: signaling transduction; neurobiochemistry; chloride homeostasis; neurodevelopmental disorders; neurodegeneration
Special Issues, Collections and Topics in MDPI journals
Interests: kinase Inhibitors; kinase non-catalytic function discovery; small molecule modulation
Special Issue Information
Dear Colleagues,
Ion channels and transporters, found in all cells, are transmembrane proteins that enable the passive flow of ions both in and out of cells or cellular organelles, following their electrochemical gradients. Proper maintenance of ion channels and transporters is critical for a range of cellular processes, such as signal transduction, neurotransmitter release, nerve impulses, muscle contraction, hormone secretion, volume regulation, growth, motility, apoptosis, and ion and water homeostasis. Dysfunction of ion channels or transporters may result in diseases of the nervous system (e.g., epilepsy), the cardiovascular system (e.g., Brugada syndrome), the respiratory system (e.g., cystic fibrosis), the endocrine system (e.g., neonatal diabetes mellitus), the urinary system (e.g., Bartter syndrome), and the immune system (e.g., Isaac syndrome).
This Special Issue welcomes the submission of original research and review articles that shed light on the importance of ion channels or transporters and the signaling pathways involved in the pathophysiology of human diseases and suggest new strategies for treatment.
Dr. Jinwei Zhang
Dr. Zhen Wang
Prof. Dr. Zhengqiu Li
Guest Editors
Manuscript Submission Information
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Keywords
- ion channel
- ion transporter
- signal transduction
- mechanism
- regulation
- human disease
- treatment
- drug discovery
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