Chlamydia trachomatis Pathogenicity and Disease 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (25 April 2024) | Viewed by 3443
Special Issue Editor
Interests: identification of host defence factors towards C. trachomatis genital infection; study of C. trachomatis role in the pathogenesis of male infertility; study of chlamydia-host cell interaction; identification of new anti-chlamydial drugs; study of the etiopathogenic role Chlamydia pneumoniae in the chronic inflammatory diseases
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Special Issue Information
Dear Colleagues,
Chlamydia trachomatis, responsible for genital infection, trachoma, and lymphogranuloma venereum according to the specific serotype, is still a relevant public health problem worldwide due to the high prevalence of asymptomatic infections in both women and men, favoring the onset of chronic complications, such as pelvic inflammatory disease and ectopic pregnancy for women, epididymitis and proctitis for men, as well as reactive arthritis and infertility for both sexes. These are likely due to the long-term persistence of C. trachomatis infection in the host organism, leading to a chronic inflammatory state and the consequent tissue damage.
To date, many critical questions on the pathogenesis of C. trachomatis infection remain to be answered. For example, the nature of the host innate immune response to C. trachomatis, as well as the virulence factors involved, is a key issue that needs further investigation to clarify the molecular and cellular mechanisms responsible for tissue damage associated to chlamydial infection.
In order to shed light on the etiopathogenesis and host cell response mechanisms of damaging C. trachomatis infection, this Special Issue is dedicated to current progress in chlamydial infection pathogenesis and related diseases.
Dr. Rosa Sessa
Guest Editor
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Keywords
- Chlamydia trachomatis
- virulence factors
- host susceptibility or resistance
- innate and adaptive
- immune responses
- genetic studies
- cervico-vaginal microbiota
- clinical outcomes with molecular study
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