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Advancements in Understanding Protein Misfolding Disorders and Cancer

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 20 January 2025 | Viewed by 1528

Special Issue Editor


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Guest Editor
Department of Internal Medicine, Nephrology Division, Ghent University Hospital, 9000 Ghent, Belgium
Interests: biochemistry; biomarkers; hypertension; cardiovascular disease; kidney disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This special issue aims to bridge the knowledge between protein misfolding disorders such as amyloidosis and cancer by exploring the molecular pathways, diagnostic methodologies, and therapeutic strategies pertinent to these diseases. We invite investigators to submit original research articles, comprehensive reviews, and insightful commentaries that contribute to a deeper understanding of these distinct yet intersecting fields. Topics of interest include but are not limited to:

  • Molecular and genetic mechanisms underlying protein misfolding and aggregation in amyloidosis and oncogenesis.
  • Advances in diagnostic technologies and methodologies for early and accurate detection of amyloidosis and cancer.
  • Cross-talk between misfolded protein pathways and cancer signaling pathways.
  • Novel therapeutic strategies targeting common molecular pathways in protein misfolding disorders and cancer.
  • Multi-disciplinary approaches for managing patients with coexisting amyloidosis and cancer.
  • Patient-centric studies exploring the impact, management, and prognosis of amyloidosis and cancer.
  • Real-world evidence and clinical case studies highlighting diagnostic challenges and treatment outcomes in amyloidosis and cancer.

Prof. Dr. Marijn Speeckaert
Guest Editor

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Keywords

  • protein misfolding
  • cancer
  • amyloidosis

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Published Papers (1 paper)

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Review

18 pages, 931 KiB  
Review
Advancing Renal Amyloidosis Care: The Role of Modern Diagnostic Techniques with the Potential of Enhancing Patient Outcomes
by Charlotte Delrue, Amélie Dendooven, Annelore Vandendriessche, Reinhart Speeckaert, Sander De Bruyne and Marijn M. Speeckaert
Int. J. Mol. Sci. 2024, 25(11), 5875; https://doi.org/10.3390/ijms25115875 - 28 May 2024
Viewed by 1050
Abstract
Renal amyloidosis is a set of complex disorders characterized by the deposition of amyloid proteins in the kidneys, which causes gradual organ damage and potential kidney failure. Recent developments in diagnostic methods, particularly mass spectrometry and proteome profiling, have greatly improved the accuracy [...] Read more.
Renal amyloidosis is a set of complex disorders characterized by the deposition of amyloid proteins in the kidneys, which causes gradual organ damage and potential kidney failure. Recent developments in diagnostic methods, particularly mass spectrometry and proteome profiling, have greatly improved the accuracy of amyloid typing, which is critical for disease management. These technologies provide extensive insights into the specific proteins involved, allowing for more targeted treatment approaches and better patient results. Despite these advances, problems remain, owing to the heterogeneous composition of amyloid proteins and the varying efficacy of treatments based on amyloid type. Access to sophisticated diagnostics and therapy varies greatly, highlighting the global difference in renal amyloidosis management. Future research is needed to investigate next-generation sequencing and gene-editing technologies, like clustered regularly interspaced short palindromic repeats (CRISPR), which promise more profound insights into the genetic basis of amyloidosis. Full article
(This article belongs to the Special Issue Advancements in Understanding Protein Misfolding Disorders and Cancer)
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