Growth Hormone Tumor: Molecular Pathologies, Diagnosis, and Therapeutic Strategies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 May 2025 | Viewed by 1751
Special Issue Editor
Interests: endocrinology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Acromegaly, an endocrine disorder secondary to the hypersecretion of growth hormone (GH or the somatotroph hormone) and insulin-like growth factor 1 (IGF-I), usually occurs due to pituitary tumors, only derived from somatotroph cells (somatotropinomas) or plurihormonal tumors, such as mammo-somatotropinomas. A timely diagnosis should be aimed for, as acromegaly is associated with remarkable complications that may reduce life expectancy. Improvement in diagnosis and management increase disease survival and ameliorate QoL in acromegalic patients. New treatment modalities became available in recent years, including somatostatin-receptor ligands (SRLs) and pegvisomant, have significantly improved standard mortality ratios. Molecular and genetic mechanisms have been extensively investigated in acromegalic patients. The identification of different molecular pathways, regulators, influence of the tumoral microenvironment, and germline and somatic mutations on several genes, such as AIP, MEN1, CDKN1B, GPR101, PRKAR1A and GNAS, impact the therapeutic approach and prognosis of these tumors. Thanks to continuous innovation in this field, treatment for acromegaly is becoming increasingly personalised, from biology to target therapy.
We are pleased to invite you to contribute to this Special Issue on growth hormone-secreting tumors.
This Special Issue aims to focus on molecular pathologies, diagnosis and therapeutic strategies in growth hormone-secreting tumors.
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but not limited to) the following: pituitary tumors, etc.
I look forward to receiving your contributions.
Dr. Sabrina Chiloiro
Guest Editor
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Keywords
- acromegaly
- growth hormone-secreting tumors
- pituitary tumors
- molecular targets
- target therapy
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