Role of Drosophila in Human Disease Research 4.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 4939
Special Issue Editors
Interests: Drosophila model for human disease; epigenetics; DNA replication gene; autism spectrum disorder
Special Issues, Collections and Topics in MDPI journals
Interests: Drosophila models
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
For over a century, Drosophila melanogaster has been widely used in classical and modern genetics. Many biological functions are highly conserved between humans and Drosophila, and nearly 85% of human-disease-causing genes have functional homologues in Drosophila. Because of this, Drosophila has been used as a highly tractable animal model for studying human diseases, with notable success in the study of various neurodegenerative diseases, metabolic syndromes, and cancer. The similarities between the mammalian and Drosophila systems have also allowed Drosophila to play a role in the evaluation of candidate substances for the treatment of these human diseases.
More recently, based on similarities in the pathways involved in DNA replication, DNA repair pathways, physical and neurological properties, Drosophila models have also started to be used to study more complex psychiatric disorders, aging, and other rare intractable human genetic diseases. However, it is always important to keep in mind both the benefits and limitations of fly models by comparing them to other animal models, such as mouse, zebra fish, and nematode worm. For this Special Issue, we welcome original research and up-to-date review articles that provide novel insights into how Drosophila models (especially models of DNA replication and repair genes) have progressed the understanding of human disease.
Dr. Masamitsu Yamaguchi
Dr. Sue Cotterill
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Drosophila melanogaster
- human disease model
- cancer
- neurodegeneration
- psychiatric disorder
- mental retardation
- metabolic syndrome
- infectious disease
- aging
- epigenetic dysregulation
- mitochondrial disorder
- DNA replication or repair defects
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
