Small Cell Lung Cancer Entering the Sphere of Personalized Treatment
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 May 2025 | Viewed by 2214
Special Issue Editors
Interests: cancer; lung cancer; DNA; RNA; miRNA; epigenetics; NGS; molecular testing
Special Issues, Collections and Topics in MDPI journals
Interests: lung cancer; oncology; NSCLC; non-small cell lung cancer; SCLC; small cell lung cancer; molecularly targeted therapy; immunotherapy; artificial intelligence
Interests: lung cancer; oncology; NSCLC; non-small cell lung cancer; SCLC; small cell lung cancer; molecularly targeted therapy; immunotherapy
Special Issue Information
Dear Colleagues,
Small cell lung cancer (SCLC) is a subtype of lung cancer, which is the most malignant, rapidly progressive and poorly prognostic cancer of the thoracic region. Overall survival is short, and therapeutic options are few. Until recently, the only systemic treatment was chemotherapy, which can cause serious adverse effects and has limited efficacy.
Recently, it became possible to use immune checkpoint inhibitors (ICIs) in combination with chemotherapy in therapy of SCLC patients. This is a big progress in the treatment of small cell lung cancer, where until now not much has been done in terms of modern therapies. Almost in parallel, we have scientific reports regarding broad-spectrum genomic and transcriptomic analysis in SCLC. There have been tremendous molecular advances in SCLC, which may provide the basis for designing and implementing targeted therapies, both with monoclonal antibodies and small-molecule therapies.
We greatly encourage scientific discussion on this very timely, extremely all-important and necessary topic.
Dr. Anna Grenda
Dr. Michał Szczyrek
Dr. Izabela Chmielewska
Guest Editors
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Keywords
- small cell lung cancer
- SCLC
- pathological subtypes
- molecular subtypes
- DNA
- RNA
- NGS
- next-generation sequencing transcriptome
- mutations
- molecular analysis
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