ijms-logo

Journal Browser

Journal Browser

Therapeutic Potential of Antioxidants in the Prevention of Human Diseases, 2nd Edition

Special Issue Editor

Special Issue Information

Dear Colleagues,

Oxidative stress has been associated with a number of complications, including infectious diseases, inflammatory complications, neurodegenerative diseases, metabolic diseases, and various cancers. Natural plant-derived products have been utilized to treat these complications for thousands of years, without much understanding of the molecular mechanism(s) via which these compounds prevent or cure these human diseases. Furthermore, several antioxidants derived from various natural resources have been tested in the past, and it has been found that their antioxidative and anti-inflammatory properties could benefit human health. Indeed, some currently available pharmaceutical drugs have been developed using compounds isolated from various plant species. Furthermore, multiple analogs of antioxidants are more potent than parent antioxidants. Although several preclinical studies indicate the beneficial effects of various antioxidants, some have never been tested in a clinical setting. Furthermore, the functions of preexisting antioxidants need to be explored and the identification of novel antioxidants with potential benefits to human health and disease must be performed. This Special Issue is dedicated to studies on various natural antioxidants and their possible analogs in the prevention and treatment of various human diseases. We welcome potential authors to contribute to this Special Issue with studies related to structural and computational studies, functional studies, preclinical and clinical research studies, and comprehensive reviews.

Dr. Kota V. Ramana
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidants
  • vitamins
  • inflammation
  • cancer
  • neurological complications
  • diabetes
  • flavonoids
  • natural compounds
  • cancer
  • infections
  • COVID-19

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Related Special Issue

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

22 pages, 4020 KiB  
Article
Methyl Derivatives of Flavone as Potential Anti-Inflammatory Compounds
by Dagmara Jaworska, Małgorzata Kłósek, Joanna Bronikowska, Agnieszka Krawczyk-Łebek, Martyna Perz, Edyta Kostrzewa-Susłow and Zenon P. Czuba
Int. J. Mol. Sci. 2025, 26(2), 729; https://doi.org/10.3390/ijms26020729 - 16 Jan 2025
Viewed by 395
Abstract
Flavones are natural compounds that are broadly distributed in our diet. Their unique properties provide the possibility to control the immune system and the process of inflammation. A high intake of flavonoids, including flavones, may offer protection against reactive oxygen species, inflammation, and [...] Read more.
Flavones are natural compounds that are broadly distributed in our diet. Their unique properties provide the possibility to control the immune system and the process of inflammation. A high intake of flavonoids, including flavones, may offer protection against reactive oxygen species, inflammation, and chronic diseases. In this research, we evaluated the anti-inflammatory effect of five methylflavones, 2′-methylflavone (5C), 3′-methylflavone (6C), 4′-methylflavone (7C), 6-methylflavone (8C), and 6-methyl-8-nitroflavone (12C), in lipopolysaccharide (LPS) stimulated RAW 264.7 cells (murine macrophage cell line). We estimated the nitrite concentration and detected reactive oxygen species using the chemiluminescence method. Moreover, we measured the production of pro-inflammatory cytokines using the Bio-Plex Magnetic Luminex Assay. As a result of our findings, we have established that some of the methyl derivatives of flavone inhibit nitric oxide (NO) production and chemiluminescence generated by LPS-stimulated macrophages, but they also have an influence on pro-inflammatory cytokines production. This study showed that 2′-methylflavone (5C) and 3′-methylflavone (6C) possess the strongest anti-inflammatory activity among all tested derivatives of flavone. In conclusion, our study demonstrated that methylflavones may be potentially valuable compounds for the alleviation of inflammatory reactions. Full article
Show Figures

Figure 1

Back to TopTop