Energy, Metabolism and Cell Fate
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (30 November 2020) | Viewed by 7179
Special Issue Editors
Interests: immunology; inflammation; microbiota; cell metabolism; transplantation; DNA repair
Special Issues, Collections and Topics in MDPI journals
Interests: immunology; inflammation; obesity; cytokines; immunity; molecular biology; apoptosis; signaling pathways; macrophage; insulin resistance
Special Issue Information
Dear Colleagues,
Metabolism is a crucial process for all living organisms. A rising body of information on the roles of metabolic pathways and metabolic sensors places immunometabolism as one of the main processes that dictates immune cell differentiation, activation, and function. Metabolic pathways, such as glycolysis, glutaminolysis, and fatty acid oxidation, as well as metabolic sensors such as mTOR, HIF, and others, have been shown to be crucial in these processes. More recently, it became clear that all these processes control physiological cell function, being extremely important in an array of diseases, such as cancer and obesity, among others. Despite being a fastgrowing field, important questions remain. Consequently, to better understand how metabolism influences cell fate in immune and non-immune cells in these different settings is of paramount interest. For instance, all these pathways can generate a lot of intermediates, also called secondary metabolites, but whether these molecules have any impact directly on cells function is just starting to be explored. At the same time, blocking these metabolic pathways and sensors could be beneficial in different immune-mediated diseases.
Thus, with this Special Issue we intend to attract original papers addressing questions that uncover the role of metabolic pathways/sensors dictating immune cells function and its impact in different diseases. Special attention will be devoted to metabolic intermediates from different metabolic pathways with the ability to influence immune cells, and the use of metabolic inhibitors to treat diseases. Outstanding reviews covering these new aspects of the immunometabolism field also will be considered in this new Special Issue. We hope this Issue contributes to a better understanding of the relationship between immune cells, metabolism, and diseases.
Potential topics include but are not limited to the following:
- Metabolic pathways on immune differentiation and function;
- Metabolic sensors on immune function;
- Treatment of immune diseases with metabolic inhibitors;
- Mechanisms of immune metabolism controlling adaptive and innate cells;
- Metabolic intermediates and their roles on immune cell function and diseases;
- Immunity and metabolism in plants.
Prof. Dr. Niels Olsen Saraiva Camara
Prof. Dr. Vinicius de Andrade Oliveira
Dr. Angela Castoli
Dr. Maria Fernanda Forni
Guest Editors
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