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Regulation of Estrogen Metabolism in Obesity
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Regulation of Estrogen Metabolism in Obesity

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (15 November 2022) | Viewed by 6203

Special Issue Editor

Dr. Alina Kuryłowicz

E-Mail Website
Guest Editor
Department of Human Epigenetics, Mossakowski Medical Research Centre PAS, 02-106 Warsaw, Poland
Interests: estrogen metabolism; adipogenesis; adipose tissue; epigenetics; microRNA; DNA methylation; obesity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

When assessing the health risks in obese individuals, not only is the amount of adipose tissue essential, but also its distribution and metabolic activity. In adults, adipose tissue distribution differs in a gender-dependent manner and is regulated by sex hormones, especially estrogen. Estrogens influence adipocyte differentiation and regulate lipid metabolism, insulin resistance, and the inflammatory activity of adipose tissue. Their deficiency results in unfavorable changes in body composition and increases the risk of metabolic complications that can be partially reversed by hormone replacement therapy. Therefore, understanding the role of estrogens in regulating adipose tissue function promises to yield novel therapeutic applications in obesity and related diseases. Epigenetic modifications play an essential role in regulating gene expression in adipose tissue; therefore, interference with these processes might be an attractive approach to counteract obesity. 

This Special Issue aims to integrate present concepts on the role of epigenetic regulation of estrogen metabolism and action in obesity. Submissions are open for original contributions as well as review articles that may broaden existing knowledge in the field and provide new concepts for the treatment of obesity-associated adipose tissue dysfunction.

Dr. Alina Kuryłowicz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • estrogen
  • estrogen receptors
  • estrogen metabolism
  • adipogenesis
  • adipose tissue
  • adipose tissue dysfunction
  • metaflammation
  • obesity
  • obesity treatment
  • bariatric surgery
  • epigenetics
  • microRNA
  • DNA methylation
  • non-coding RNA
  • histone modification

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Published Papers (2 papers)

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Research

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19 pages, 1774 KiB  
Article
Epigenetic Regulation of Estrogen Receptor Genes’ Expressions in Adipose Tissue in the Course of Obesity
by Krzysztof Koźniewski, Michał Wąsowski, Marta Izabela Jonas, Wojciech Lisik, Maurycy Jonas, Artur Binda, Paweł Jaworski, Wiesław Tarnowski, Bartłomiej Noszczyk, Monika Puzianowska-Kuźnicka and Alina Kuryłowicz
Int. J. Mol. Sci. 2022, 23(11), 5989; https://doi.org/10.3390/ijms23115989 - 26 May 2022
Cited by 8 | Viewed by 2215
Abstract
Estrogen affects adipose tissue function. Therefore, this study aimed at assessing changes in the transcriptional activity of estrogen receptor (ER) α and β genes (ESR1 and ESR2, respectively) in the adipose tissues of obese individuals before and after weight loss and [...] Read more.
Estrogen affects adipose tissue function. Therefore, this study aimed at assessing changes in the transcriptional activity of estrogen receptor (ER) α and β genes (ESR1 and ESR2, respectively) in the adipose tissues of obese individuals before and after weight loss and verifying whether epigenetic mechanisms were involved in this phenomenon. ESR1 and ESR2 mRNA and miRNA levels were evaluated using real-time PCR in visceral (VAT) and subcutaneous adipose tissue (SAT) of 78 obese (BMI > 40 kg/m2) and 31 normal-weight (BMI = 20–24.9 kg/m2) individuals and in 19 SAT samples from post-bariatric patients. ESR1 and ESR2 methylation status was studied using the methylation-sensitive digestion/real-time PCR method. Obesity was associated with a decrease in mRNA levels of both ERs in SAT (p < 0.0001) and ESR2 in VAT (p = 0.0001), while weight loss increased ESR transcription (p < 0.0001). Methylation levels of ESR1 and ESR2 promoters were unaffected. However, ESR1 mRNA in the AT of obese subjects correlated negatively with the expression of hsa-miR-18a-5p (rs = −0.444), hsa-miR-18b-5p (rs = −0.329), hsa-miR-22-3p (rs = −0.413), hsa-miR-100-5p (rs = −0.371), and hsa-miR-143-5p (rs = −0.289), while the expression of ESR2 in VAT correlated negatively with hsa-miR-576-5p (rs = −0.353) and in SAT with hsa-miR-495-3p (rs = −0.308). In conclusion, obesity-associated downregulation of ER mRNA levels in adipose tissue may result from miRNA interference. Full article
(This article belongs to the Special Issue Regulation of Estrogen Metabolism in Obesity)
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Review

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24 pages, 1583 KiB  
Review
Obesity as a Risk Factor for Breast Cancer—The Role of miRNA
by Karolina Hanusek, Jakub Karczmarski, Anna Litwiniuk, Katarzyna Urbańska, Filip Ambrozkiewicz, Andrzej Kwiatkowski, Lidia Martyńska, Anita Domańska, Wojciech Bik and Agnieszka Paziewska
Int. J. Mol. Sci. 2022, 23(24), 15683; https://doi.org/10.3390/ijms232415683 - 10 Dec 2022
Cited by 7 | Viewed by 3397
Abstract
Breast cancer (BC) is the most common cancer diagnosed among women in the world, with an ever-increasing incidence rate. Due to the dynamic increase in the occurrence of risk factors, including obesity and related metabolic disorders, the search for new regulatory mechanisms is [...] Read more.
Breast cancer (BC) is the most common cancer diagnosed among women in the world, with an ever-increasing incidence rate. Due to the dynamic increase in the occurrence of risk factors, including obesity and related metabolic disorders, the search for new regulatory mechanisms is necessary. This will help a complete understanding of the pathogenesis of breast cancer. The review presents the mechanisms of obesity as a factor that increases the risk of developing breast cancer and that even initiates the cancer process in the female population. The mechanisms presented in the paper relate to the inflammatory process resulting from current or progressive obesity leading to cell metabolism disorders and disturbed hormonal metabolism. All these processes are widely regulated by the action of microRNAs (miRNAs), which may constitute potential biomarkers influencing the pathogenesis of breast cancer and may be a promising target of anti-cancer therapies. Full article
(This article belongs to the Special Issue Regulation of Estrogen Metabolism in Obesity)
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