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Fascial Anatomy and Histology: Advances in Molecular Biology

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (20 November 2024) | Viewed by 1065

Special Issue Editor

Special Issue Information

Dear Colleagues,

The structural and functional importance of the fascial system has largely been overlooked by the therapeutic community in the past. Recent research has demonstrated that fascia is highly innervated and probably our most sensitive organ for proprioception, particularly the deep layers. Exteroceptive receptors appear to reside more within the superficial fascia. In addition, it is evident that there are many different types of fasciae, and each one serves multiple functional roles. The superficial fascia is more related to lymph drainage and skin tropism and has strong anatomical relationships with the superficial vessels and nerves. The deep fascia is more related to the muscles, ligaments, and tendons, and plays a key function in proprioception and motor coordination. Finally, the visceral fasciae support the organs and interact with the autonomic nervous system. With this Special Issue, we aim to gain a better understanding of the various features of each fascia, considering their involvement in various pathologies, such as myofascial pain, lipoedema, and fibromyalgia. Also, papers focused on the interactions between fasciae and the metabolic and immunological systems are welcome.

Prof. Dr. Carla Stecco
Guest Editor

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Keywords

  • fascia
  • connective tissue
  • myofascial pain
  • collagen
  • hyaluronan

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Published Papers (1 paper)

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Research

16 pages, 3667 KiB  
Article
The Impact of Sciatic Nerve Injury on Extracellular Matrix of Lower Limb Muscle and Thoracolumbar Fascia: An Observational Study
by Xiaoxiao Zhao, Caterina Fede, Lucia Petrelli, Carmelo Pirri, Elena Stocco, Chenglei Fan, Andrea Porzionato, Cesare Tiengo, Raffaele De Caro, Stefano Masiero and Carla Stecco
Int. J. Mol. Sci. 2024, 25(16), 8945; https://doi.org/10.3390/ijms25168945 - 16 Aug 2024
Viewed by 802
Abstract
Peripheral nerve injury (PNI) is a complex clinical challenge resulting in functional disability. Neurological recovery does not always ensure functional recovery, as extracellular matrix (ECM) alterations affect muscle function. This study evaluates hyaluronan (HA) and collagen concentration in the gastrocnemius muscle and thoracolumbar [...] Read more.
Peripheral nerve injury (PNI) is a complex clinical challenge resulting in functional disability. Neurological recovery does not always ensure functional recovery, as extracellular matrix (ECM) alterations affect muscle function. This study evaluates hyaluronan (HA) and collagen concentration in the gastrocnemius muscle and thoracolumbar fascia (TLF) in unilateral lower limb PNI rats to explore systemic ECM alterations following PNI and their impacts on functional recovery. Eighteen 8-week-old male Sprague-Dawley rats were divided into experimental (n = 12 left sciatic nerve injury) and control (n = 6) groups. After six weeks, motor function was evaluated. Muscle and TLF samples were analysed for HA and collagen distribution and concentrations. SFI and gait analysis confirmed a functional deficit in PNI rats 6 weeks after surgery. HA concentration in both sides of the muscles decreased by approximately one-third; both sides showed significantly higher collagen concentration than healthy rats (12.74 ± 4.83 µg/g), with the left (32.92 ± 11.34 µg/g) significantly higher than the right (20.15 ± 7.03 µg/g). PNI rats also showed significantly lower HA (left: 66.95 ± 20.08 µg/g; right: 112.66 ± 30.53 µg/g) and higher collagen (left: 115.89 ± 28.18 µg/g; right: 90.43 ± 20.83 µg/g) concentrations in both TLF samples compared to healthy rats (HA: 167.18 ± 31.13 µg/g; collagen: 47.51 ± 7.82 µg/g), with the left TLF more affected. Unilateral lower limb PNI induced HA reduction and collagen accumulation in both the lower limb muscles and the TLF, potentially exacerbating motor function impairment and increasing the risk of low back dysfunctions. Full article
(This article belongs to the Special Issue Fascial Anatomy and Histology: Advances in Molecular Biology)
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