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New Sights into the Serotonin System, Obesity and Diabetes
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New Sights into the Serotonin System, Obesity and Diabetes

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 15 March 2025 | Viewed by 2079

Special Issue Editor

Prof. Dr. Katsunori Nonogaki

E-Mail Website
Guest Editor
Division of Diabetes and Nutrition, RARiS, Tohoku University, Sendai 980-8579, Japan
Interests: bile acids; serotonin; serotonin receptor; Tph1; Tph2; tryptophan metabolites; GLP-1; GLP-1 receptor agonists; FGF21; FGF15/19; neuropeptides; gut-derived hormones; liver-derived hormones; obesity; diabetes; appetite; food intake; hypothalamus; energy homeostasis; hepatosteatosis; glucose metabolism; lipid metabolism; organ network; whey protein; soy protein; insulin, leptin, insulin resistance; adipose tissue; CNS; gene expression; sympathetic nervous system
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Special Issue Information

Dear Colleagues,

Serotonin (5-HT) is a hormone secreted mainly from EC cells in the gut and is a neurotransmitter in the brain. The 5-HT system can be altered by stress, diet and microbiota, and contributes overall to the pathophysiological mechanisms of metabolic diseases including obesity, diabetes and NAFLD. The 5-HT system has been therefore suggested as a novel therapeutic target for the treatment of metabolic diseases. This Special Issue aims to provide new insights into the 5-HT system, obesity and diabetes, and explore the novel regulatory system of 5-HT, 5-HT receptors and 5-HT transporters, and well as the overall role of the 5-HT system in the regulation of metabolic diseases. Original papers and reviews are welcome.

Prof. Dr. Katsunori Nonogaki
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • serotonin
  • serotonin receptor
  • serotonin transporter, energy metabolism
  • nutrients
  • microbiota, hormones
  • obesity
  • hepatosteatosis
  • diabetes

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Published Papers (1 paper)

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Research

21 pages, 9770 KiB  
Article
Downregulation of Serotonergic System Components in an Experimentally Induced Cryptorchidism in Rabbits
by Francisco Jiménez-Trejo, Cristian Arriaga-Canon, Luis A. Herrera, Isabel Coronado-Mares, Rogelio Montiel-Manríquez, Isaac González-Santoyo, Wendy B. Pérez-Báez and Miguel Tapia-Rodríguez
Int. J. Mol. Sci. 2024, 25(6), 3149; https://doi.org/10.3390/ijms25063149 - 9 Mar 2024
Viewed by 1609
Abstract
Cryptorchidism (CO) or undescended testes is defined as the failure of one or both testes to be positioned inside the scrotum. Typically, cryptorchidism is detected at birth or shortly thereafter, and in humans, it is considered to be part of the testicular dysgenesis [...] Read more.
Cryptorchidism (CO) or undescended testes is defined as the failure of one or both testes to be positioned inside the scrotum. Typically, cryptorchidism is detected at birth or shortly thereafter, and in humans, it is considered to be part of the testicular dysgenesis syndrome (TDS), a complex pathology regarding the male reproductive system that apparently involves the interaction of both genetic and environmental harmful factors, mainly during embryonic development. Serotonin (5-HT) is an ancient molecule that participates in a broad range of body functions, and in recent years, its importance in reproduction has started to be elucidated. In male pathologies such as infertility, varicocele, erectile dysfunction, and primary carcinoid tumors, an increase in 5-HT concentration or its metabolites in the blood, semen, and urine has been directly related; nevertheless, the role of 5-HT in CO remains unknown. In the present work, our goal was to answer two important questions: (1) whether some serotonergic system components are present in adult male Oryctolagus cuniculus (chinchilla rabbit) and (2) if there are changes in their expression in an experimental model of CO. Using histological, molecular, and biochemical approaches, we found the presence of some serotonergic system components in the adult chinchilla rabbit, and we demonstrated that its expression is downregulated after CO was pharmacologically induced. Although we did not test the role of 5-HT in the etiology of CO, our results suggest that this indoleamine could be important for the regulation of steroidogenesis and spermatogenesis processes in the chinchilla rabbit during adulthood. Finally, in parallel experimental series, we found downregulation of kynurenine concentration in COI rabbits when compared to control ones, suggesting that CO could be affecting the kynurenine pathway and probably testicular immune privilege which in turn could lead to infertility/sterility conditions in this disorder. Full article
(This article belongs to the Special Issue New Sights into the Serotonin System, Obesity and Diabetes)
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