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The Microbiota and Its Association with Cellular Transformation and Metabolic Changes, 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 20 December 2024 | Viewed by 5679

Special Issue Editors

Dr. Davide Zella

E-Mail Website
Guest Editor
Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
Interests: human microbiota; cancer biology; p53; DNA repair; DnaK; cellular transformation
Special Issues, Collections and Topics in MDPI journals
Dr. Francesca Benedetti

E-Mail Website
Guest Editor
Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
Interests: microbiota; cancer biology; p53; DnaK
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, scientists have made significant discoveries concerning the link between human microbiota and both human cancers and metabolic changes. New findings suggest altered immune responses, metabolism shifts, and dysregulated kinase activation, which potentially impairs cellular signal transduction. In vitro studies have also revealed that certain bacteria can drive epigenetic changes, modify host cell cycles, influence apoptotic pathways, and stimulate the production of inflammatory substances that may cause DNA damage. This damage could potentially promote abnormal cell growth and transformation. Additionally, in vivo experiments have demonstrated that administering cancer-causing agents to germ-free animals results in less tumor formation compared to non-germ-free mice. Furthermore, human studies have emphasized the association between specific bacteria such as H. pylori, F. nucleatum, and certain mycoplasmas, and the origin of some cancers. However, the exact mechanisms of cellular transformation remain largely mysterious. This Special Issue aims to gather original research articles and review papers exploring any aspect of the interaction between the human microbiota and host cells. The focus of this Special Issue is on the description and elucidation of the potential molecular mechanisms that may promote cellular transformation and metabolic changes. To further underscore the role of human microbiota on metabolic changes, we also encourage the submission of papers examining its effects on cardiovascular diseases, diabetes, and reproductive issues, among others.

Dr. Davide Zella
Dr. Francesca Benedetti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Published Papers (2 papers)

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Review

13 pages, 670 KiB  
Review
The Gut and Skin Microbiome and Its Association with Aging Clocks
by Mildred Min, Caitlin Egli and Raja K. Sivamani
Int. J. Mol. Sci. 2024, 25(13), 7471; https://doi.org/10.3390/ijms25137471 - 8 Jul 2024
Cited by 1 | Viewed by 2294
Abstract
Aging clocks are predictive models of biological age derived from age-related changes, such as epigenetic changes, blood biomarkers, and, more recently, the microbiome. Gut and skin microbiota regulate more than barrier and immune function. Recent studies have shown that human microbiomes may predict [...] Read more.
Aging clocks are predictive models of biological age derived from age-related changes, such as epigenetic changes, blood biomarkers, and, more recently, the microbiome. Gut and skin microbiota regulate more than barrier and immune function. Recent studies have shown that human microbiomes may predict aging. In this narrative review, we aim to discuss how the gut and skin microbiomes influence aging clocks as well as clarify the distinction between chronological and biological age. A literature search was performed on PubMed/MEDLINE databases with the following keywords: “skin microbiome” OR “gut microbiome” AND “aging clock” OR “epigenetic”. Gut and skin microbiomes may be utilized to create aging clocks based on taxonomy, biodiversity, and functionality. The top contributing microbiota or metabolic pathways in these aging clocks may influence aging clock predictions and biological age. Furthermore, gut and skin microbiota may directly and indirectly influence aging clocks through the regulation of clock genes and the production of metabolites that serve as substrates or enzymatic regulators. Microbiome-based aging clock models may have therapeutic potential. However, more research is needed to advance our understanding of the role of microbiota in aging clocks. Full article
(This article belongs to the Special Issue The Microbiota and Its Association with Cellular Transformation and Metabolic Changes, 2nd Edition)
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16 pages, 896 KiB  
Review
Role of the Gut Microbiota in Osteoarthritis, Rheumatoid Arthritis, and Spondylarthritis: An Update on the Gut–Joint Axis
by Umile Giuseppe Longo, Alberto Lalli, Benedetta Bandini, Roberto de Sire, Silvia Angeletti, Sebastien Lustig, Antonio Ammendolia, Nicolaas Cyrillus Budhiparama and Alessandro de Sire
Int. J. Mol. Sci. 2024, 25(6), 3242; https://doi.org/10.3390/ijms25063242 - 13 Mar 2024
Cited by 4 | Viewed by 2816
Abstract
Dysregulation of the gut microbiota and their metabolites is involved in the pathogenic process of intestinal diseases, and several pieces of evidence within the current literature have also highlighted a possible connection between the gut microbiota and the unfolding of inflammatory pathologies of [...] Read more.
Dysregulation of the gut microbiota and their metabolites is involved in the pathogenic process of intestinal diseases, and several pieces of evidence within the current literature have also highlighted a possible connection between the gut microbiota and the unfolding of inflammatory pathologies of the joints. This dysregulation is defined as the “gut-joint axis” and is based on the joint–gut interaction. It is widely recognized that the microbiota of the gut produce a variety of compounds, including enzymes, short-chain fatty acids, and metabolites. As a consequence, these proinflammatory compounds that bacteria produce, such as that of lipopolysaccharide, move from the “leaky gut” to the bloodstream, thereby leading to systemic inflammation which then reaches the joints, with consequences such as osteoarthritis, rheumatoid arthritis, and spondylarthritis. In this state-of-the-art research, the authors describe the connections between gut dysbiosis and osteoarthritis, rheumatoid arthritis, and spondylarthritis. Moreover, the diagnostic tools, outcome measures, and treatment options are elucidated. There is accumulating proof suggesting that the microbiota of the gut play an important part not only in immune-mediated, metabolic, and neurological illnesses but also in inflammatory joints. According to the authors, future studies should concentrate on developing innovative microbiota-targeted treatments and their effects on joint pathology as well as on organizing screening protocols to predict the onset of inflammatory joint disease based on gut dysbiosis. Full article
(This article belongs to the Special Issue The Microbiota and Its Association with Cellular Transformation and Metabolic Changes, 2nd Edition)
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