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Enantioselective Homogenous Catalysis in the Presence of Small Molecules of Natural Origin

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Physical Chemistry and Chemical Physics".

Deadline for manuscript submissions: 20 December 2024 | Viewed by 1035

Special Issue Editor


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Guest Editor
Faculty of Chemistry, University of Warsaw, L Pasteura 1, PL-02-093 Warsaw, Poland
Interests: organic chemistry; organic syntheses; organic zinc compounds

Special Issue Information

Dear Colleagues,

Enantioselective reactions became a basic tool for asymmetric organic synthesis. In recent years, development in this field has been impressive. Enantioselective reactions cover new areas, such as radical chemistry, which seemed impossible at the turn of the century. However, the scientific community and pharmaceutical industry are still looking for new, more effective ligands that will enable the synthesis of novel, enantiomerically pure compounds with the highest possible selectivity.

This Special Issue is devoted to ligands derived from small chiral compounds of natural origin, including amino acids, monosaccharides and terpenes, and their design, modifications and applications in various areas of enantioselective synthesis.

We encourage all researchers wishing to share their achievements in this field and present original contributions or review articles to submit their work.

Prof. Dr. Tomasz Bauer
Guest Editor

Manuscript Submission Information

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Keywords

  • homogenous catalysis
  • ligands derived from small chiral compounds of natural origin
  • asymmetric organic synthesis

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Published Papers (1 paper)

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Research

16 pages, 2244 KiB  
Article
Synthesis of Novel 3-Deoxy-3-thio Derivatives of d-Glucosamine and Their Application as Ligands for the Enantioselective Addition of Diethylzinc to Benzaldehyde
by Yusuf Zaim Hakim and Tomasz Bauer
Int. J. Mol. Sci. 2024, 25(10), 5542; https://doi.org/10.3390/ijms25105542 - 19 May 2024
Viewed by 741
Abstract
A series of novel thio-derivatives of d-glucosamine has been synthesized using double inversion procedures at the C3 atom. New compounds were applied as ligands for the diethylzinc addition to benzaldehyde and the products of the addition were obtained with a low to [...] Read more.
A series of novel thio-derivatives of d-glucosamine has been synthesized using double inversion procedures at the C3 atom. New compounds were applied as ligands for the diethylzinc addition to benzaldehyde and the products of the addition were obtained with a low to good enantiomeric ratio. The direction and the level of the asymmetric induction were highly dependent on the type of protecting groups on the nitrogen and sulfur atoms. Full article
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