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G Protein-Coupled Receptors in Metabolic Function
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G Protein-Coupled Receptors in Metabolic Function

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 2416

Special Issue Editors

Prof. Dr. Billy KC Chow

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Guest Editor
School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong
Interests: GPCR; brain–gut peptides; drug development; structure–function of class II ligand–GPCR; hydromineral homeostasis; neuroendocrinology
Special Issues, Collections and Topics in MDPI journals
Dr. Chi Bun Chan

E-Mail Website
Guest Editor
School of Biological Sciences, The University of Hong Kong, Hong Kong SAR, China
Interests: obesity; insulin resistance; lipid metabolism; Kinase; mitochondria dynamics
Dr. Yan Li

E-Mail Website1 Website2
Guest Editor
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China
Interests: nutrition; food science; cereal; metabolism; metabolic homeostasis; obesity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The G protein-coupled receptors (GPCRs) superfamily enable our cells to sense and decode a multitude of extracellular signals, regulating multiple intracellular signaling pathways. More recently, tremendous progress has been made in elucidating the structural basis of GPCR signaling. Indeed, recent data, mainly obtained through innovative microscopy methods, show that GPCRs are far more complex and dynamic than previously thought, capable of sending intricate signals at the cell surface and inner membrane involving numerous biochemical responses and diverse pathophysiological activities. GPCRs initiate multiple signaling pathways through G-protein signaling, regulating nearly all physiological functions. Thus, GPCR dysregulation is related to a variety of human diseases and disorders. This Special Issue cordially invites researchers working with the physiological functions of GPCRs in distinct metabolic pathways to submit both original articles and reviews about the functional roles of GPCRs in the triggering, promotion, prevention and treatment of various metabolic diseases.

Prof. Dr. Billy KC Chow
Dr. Chi Bun Chan
Dr. Yan Li
Guest Editors

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Keywords

  • metabolism
  • GPCR
  • insulin
  • glucagon
  • leptin
  • IGF

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Published Papers (1 paper)

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Research

18 pages, 4598 KiB  
Article
Study on the Mechanism of MC5R Participating in Energy Metabolism of Goose Liver
by Jinqi Zhang, Ya Xing, Fangbo Li, Ji’an Mu, Tongjun Liu, Jing Ge, Minmeng Zhao, Long Liu, Daoqing Gong and Tuoyu Geng
Int. J. Mol. Sci. 2023, 24(10), 8648; https://doi.org/10.3390/ijms24108648 - 12 May 2023
Cited by 3 | Viewed by 2080
Abstract
Nutrition and energy levels have an important impact on animal growth, production performance, disease occurrence and health recovery. Previous studies indicate that melanocortin 5 receptor (MC5R) is mainly involved in the regulations of exocrine gland function, lipid metabolism and immune response in animals. [...] Read more.
Nutrition and energy levels have an important impact on animal growth, production performance, disease occurrence and health recovery. Previous studies indicate that melanocortin 5 receptor (MC5R) is mainly involved in the regulations of exocrine gland function, lipid metabolism and immune response in animals. However, it is not clear how MC5R participates in the nutrition and energy metabolism of animals. To address this, the widely used animal models, including the overfeeding model and the fasting/refeeding model, could provide an effective tool. In this study, the expression of MC5R in goose liver was first determined in these models. Goose primary hepatocytes were then treated with nutrition/energy metabolism-related factors (glucose, oleic acid and thyroxine), which is followed by determination of MC5R gene expression. Moreover, MC5R was overexpressed in goose primary hepatocytes, followed by identification of differentially expressed genes (DEGs) and pathways subjected to MC5R regulation by transcriptome analysis. At last, some of the genes potentially regulated by MC5R were also identified in the in vivo and in vitro models, and were used to predict possible regulatory networks with PPI (protein–protein interaction networks) program. The data showed that both overfeeding and refeeding inhibited the expression of MC5R in goose liver, while fasting induced the expression of MC5R. Glucose and oleic acid could induce the expression of MC5R in goose primary hepatocytes, whereas thyroxine could inhibit it. The overexpression of MC5R significantly affected the expression of 1381 genes, and the pathways enriched with the DEGs mainly include oxidative phosphorylation, focal adhesion, ECM–receptor interaction, glutathione metabolism and MAPK signaling pathway. Interestingly, some pathways are related to glycolipid metabolism, including oxidative phosphorylation, pyruvate metabolism, citrate cycle, etc. Using the in vivo and in vitro models, it was demonstrated that the expression of some DEGs, including ACSL1, PSPH, HMGCS1, CPT1A, PACSIN2, IGFBP3, NMRK1, GYS2, ECI2, NDRG1, CDK9, FBXO25, SLC25A25, USP25 and AHCY, was associated with the expression of MC5R, suggesting these genes may mediate the biological role of MC5R in these models. In addition, PPI analysis suggests that the selected downstream genes, including GYS2, ECI2, PSPH, CPT1A, ACSL1, HMGCS1, USP25 and NDRG1, participate in the protein–protein interaction network regulated by MC5R. In conclusion, MC5R may mediate the biological effects caused by changes in nutrition and energy levels in goose hepatocytes through multiple pathways, including glycolipid-metabolism-related pathways. Full article
(This article belongs to the Special Issue G Protein-Coupled Receptors in Metabolic Function)
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