The Utility and Relevance of Comprehensive Genomic Profiling in Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 4043
Special Issue Editor
Interests: urothelial cancer; sarcoma; molecular pathology; experimental therapeutics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In the past, surgery was the mainstay of solid tumor in its early stage, and chemotherapy and experimental therapies were the therapeutic cornerstones in unresectable and metastatic lesions. However, recent advances in next-generation-sequencing-based genomic profiling has dramatically hastened the disclosure of the biological and immune landscapes of cancer, leading to the development of potential biomarkers carrying prognostic and/or therapeutic relevance. The application of whole-genome/exome sequencing or well-designed comprehensive genomic profiling not only confers an opportunity for more precise cancer diagnosis, but also more individualized therapeutics. Moreover, it is also helpful in the accumulation of cancer genomic datasets to allow integrative analysis on various molecular profiling for the identification of distinct molecular/histological subtypes of cancers with diverse clinical behaviors and potential sensitivity to various therapies. It has also led to the disclosure of frequently altered genes and proteins that could lead to the perturbation of intracellular signaling pathways and their microenvironment. In the present Issue, we aim to determine the most up-to-date advances driven by comprehensive genomic profiling in the field of molecular diagnostics and theranostics.
Prof. Dr. Chien-Feng Li
Guest Editor
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Keywords
- cancer
- carcinoma
- sarcoma
- next-generation sequencing
- genomic
- mutation
- fusion
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