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Updates on Synthetic and Natural Antioxidants
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Updates on Synthetic and Natural Antioxidants

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 20 April 2025 | Viewed by 3398

Special Issue Editors

Prof. Dr. Izabela Sadowska-Bartosz

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Guest Editor
Laboratory of Analytical Biochemistry, Institute of Food Technology and Nutrition, College of Natural Sciences, University of Rzeszow, Rzeszow, Poland
Interests: biochemistry of oxidative stress; antioxidants; enzymology; neurobiology; biogerontology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Grzegorz Bartosz

E-Mail Website
Guest Editor
Institute of Food Technology and Nutrition, College of Natural Sciences, University of Rzeszow, Rzeszow, Poland
Interests: free radicals; reactive oxygen species; antioxidants; membranes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Our knowledge in the field of antioxidants is rapidly expanding due to the extensive research on both natural and synthetic antioxidants. New natural antioxidants are being discovered, and new semi-synthetic and synthetic antioxidants are being produced. Studies on the mechanisms of action of antioxidants, interactions between antioxidants, and the beneficial and adverse effects of antioxidant compounds are being performed.

As a Guest Editor of the Special Issue “Updates on Synthetic and Natural Antioxidants” of IJMS, I invite you to contribute articles presenting the latest research addressing the occurrence, chemistry, biochemistry, cellular effects, and organismal effects of antioxidants and plant stress mechanisms at the biochemical, physiological, molecular, and genetic levels. Further, contributions describing new methods, protocols, and devices for studying antioxidants are welcome.

Prof. Dr. Izabela Sadowska-Bartosz
Prof. Dr. Grzegorz Bartosz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidants
  • synthetic
  • natural compounds

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Published Papers (3 papers)

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Research

16 pages, 306 KiB  
Article
Comprehensive Phytochemical Profiling of Ulva lactuca from the Adriatic Sea
by Zorana Mutavski, Igor Jerković, Nada Ćujić Nikolić, Sanja Radman, Ivana Flanjak, Krunoslav Aladić, Drago Šubarić, Jelena Vulić and Stela Jokić
Int. J. Mol. Sci. 2024, 25(21), 11711; https://doi.org/10.3390/ijms252111711 - 31 Oct 2024
Viewed by 543
Abstract
The potential of the green macroalga Ulva lactuca is increasingly recognized, not only for its environmental benefits, but also for its applications in various industries, including food, pharmaceuticals, and cosmetics. Given this insight, a comprehensive analysis of the chemical profile of U. lactuca [...] Read more.
The potential of the green macroalga Ulva lactuca is increasingly recognized, not only for its environmental benefits, but also for its applications in various industries, including food, pharmaceuticals, and cosmetics. Given this insight, a comprehensive analysis of the chemical profile of U. lactuca from the Adriatic Sea was carried out. The hydrodistillate, rich in (Z,Z,Z)-hexadeca-7,10,13-trienal and hexadecanoic acid, underlines its importance for health-related uses, particularly in lipid metabolism and cellular integrity. Fatty acid analysis showed a predominance of palmitic acid and a favorable n-6/n-3 polyunsaturated fatty acid ratio, suggesting that U. lactuca can make a valuable contribution to a balanced diet. In addition, essential amino acids, including leucine, valine, and isoleucine, support its use as a functional ingredient for muscle repair and metabolic health. The ethanol extract contained 56 compounds, including derivatives of fatty acids, phenolic acids, pigments, flavonoids, and steroids. Many of them, such as hexadecasphinganine, azelaic acid, 5-sulfosalicylic acid, and pheophytin a, have proven roles or potentials in promoting human health. These results confirm that U. lactuca is a rich source of bioactive compounds, emphasizing its potential in scientific research and its expanding industrial applications in health, nutrition, and cosmetics. Full article
(This article belongs to the Special Issue Updates on Synthetic and Natural Antioxidants)
24 pages, 9302 KiB  
Article
Cholinesterase Inhibition and Antioxidative Capacity of New Heteroaromatic Resveratrol Analogs: Synthesis and Physico—Chemical Properties
by Milena Mlakić, Stanislava Talić, Ilijana Odak, Danijela Barić, Ivana Šagud and Irena Škorić
Int. J. Mol. Sci. 2024, 25(13), 7401; https://doi.org/10.3390/ijms25137401 - 5 Jul 2024
Viewed by 1112
Abstract
The targeted compounds in this research, resveratrol analogs 1–14, were synthesized as mixtures of isomers by the Wittig reaction using heterocyclic triphenylphosphonium salts and various benzaldehydes. The planned compounds were those possessing the trans-configuration as the biologically active trans [...] Read more.
The targeted compounds in this research, resveratrol analogs 1–14, were synthesized as mixtures of isomers by the Wittig reaction using heterocyclic triphenylphosphonium salts and various benzaldehydes. The planned compounds were those possessing the trans-configuration as the biologically active trans-resveratrol. The pure isomers were obtained by repeated column chromatography in various isolated yields depending on the heteroaromatic ring. It was found that butyrylcholinesterase (BChE) was more sensitive to the heteroaromatic resveratrol analogs than acetylcholinesterase (AChE), except for 6, the methylated thiophene derivative with chlorine, which showed equal inhibition toward both enzymes. Compounds 5 and 8 achieved the highest BChE inhibition with IC50 values of 22.9 and 24.8 μM, respectively. The same as with AChE and BChE, methylated thiophene subunits of resveratrol analogs showed better enzyme inhibition than unmethylated ones. Two antioxidant spectrophotometric methods, DPPH and CUPRAC, were applied to determine the antioxidant potential of new heteroaromatic resveratrol analogs. The molecular docking of these compounds was conducted to visualize the ligand-active site complexes’ structure and identify the non-covalent interactions responsible for the complex’s stability, which influence the inhibitory potential. As ADME properties are crucial in developing drug product formulations, they have also been addressed in this work. The potential genotoxicity is evaluated by in silico studies for all compounds synthesized. Full article
(This article belongs to the Special Issue Updates on Synthetic and Natural Antioxidants)
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16 pages, 4424 KiB  
Article
Effect of Garlic Extract on the Erythrocyte as a Simple Model Cell
by Paulina Furdak, Grzegorz Bartosz, Ireneusz Stefaniuk, Bogumił Cieniek, Edyta Bieszczad-Bedrejczuk, Mirosław Soszyński and Izabela Sadowska-Bartosz
Int. J. Mol. Sci. 2024, 25(10), 5115; https://doi.org/10.3390/ijms25105115 - 8 May 2024
Cited by 1 | Viewed by 1269
Abstract
Garlic is known to have diverse effects on mammalian cells, being cytotoxic, especially to cancer cells, but also protect against oxidative stress. Mammalian erythrocyte is a simple cell devoid of intracellular organelles, protein synthesis ability, and most signaling pathways. Therefore, examination of the [...] Read more.
Garlic is known to have diverse effects on mammalian cells, being cytotoxic, especially to cancer cells, but also protect against oxidative stress. Mammalian erythrocyte is a simple cell devoid of intracellular organelles, protein synthesis ability, and most signaling pathways. Therefore, examination of the effects of garlic on erythrocytes allows for revealing primary events in the cellular action of garlic extract. In this study, human erythrocytes or erythrocyte membranes were exposed to garlic extract at various dilutions. Hemoglobin oxidation to methemoglobin, increased binding of hemoglobin to the membrane, and formation of Heinz bodies were observed. Garlic extract depleted acid-soluble thiols, especially glutathione, and induced a prooxidative shift in the cellular glutathione redox potential. The extract increased the osmotic fragility of erythrocytes, induced hemolysis, and inhibited hemolysis in isotonic ammonium chloride, indicative of decreased membrane permeability for Cl− and increased the membrane fluidity. Fluorescent probes indicated an increased level of reactive oxygen species and induction of lipid peroxidation, but these results should be interpreted with care since the extract alone induced oxidation of the probes (dichlorodihydrofluorescein diacetate and BODIPY C11). These results demonstrate that garlic extract induces oxidative changes in the erythrocyte, first of all, thiol and hemoglobin oxidation. Full article
(This article belongs to the Special Issue Updates on Synthetic and Natural Antioxidants)
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