ijms-logo

Journal Browser

Journal Browser

Bacterial Infections and Immunodeficiency: New Insights into an Old Story

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: closed (30 May 2020) | Viewed by 15731

Special Issue Editor


E-Mail Website
Guest Editor
Dipartimento di Medicina Molecolare, Sapienza, Università di Roma, AOU Policlinico Umberto I, Roma, Italy
Interests: primary immunodeficiencies; vaccines; anti-infectious immunity; mucosal immunity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The aim of this update on bacterial infections and primary immunodeficiency (PID) is to provide new insights into the current state of knowledge on the interaction between microbes and humans. PID diseases were first recognized in patients with an increased susceptibility to bacterial infections resulting from defined genetic defects of the immune system. The susceptibility might be to many or few pathogens and might cause a spectrum of diseases ranging from mild to life-threatening infections. In recent years, our knowledge of the pathogenesis of abnormalities of the interplay between bacteria and the immune protective mechanisms has increased due the growth number of patients recognized as affected by a PID disease, the identification of new PID entities, better knowledge of the local immunity, bacterial colonization and microbiota composition, and new information on bacterial virulence factors. In the light of these recent data, the bacteria–human relationship needs to be periodically updated to provide information for future therapeutic strategies.

Prof. Dr. Isabella Quinti
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Primary immune deficiencies
  • Genetic defects
  • Immune pathways
  • Bacterial infections
  • Bacterial susceptibility
  • Bacterial virulence
  • Immune defects
  • Bacterial colonization
  • Microbiota
  • Anti-microbial treatments

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Jump to: Review

14 pages, 2999 KiB  
Article
The Importance of Porins and β-Lactamase in Outer Membrane Vesicles on the Hydrolysis of β-Lactam Antibiotics
by Si Won Kim, Jung Seok Lee, Seong Bin Park, Ae Rin Lee, Jae Wook Jung, Jin Hong Chun, Jassy Mary S. Lazarte, Jaesung Kim, Jong-Su Seo, Jong-Hwan Kim, Jong-Wook Song, Min Woo Ha, Kim D. Thompson, Chang-Ro Lee, Myunghwan Jung and Tae Sung Jung
Int. J. Mol. Sci. 2020, 21(8), 2822; https://doi.org/10.3390/ijms21082822 - 17 Apr 2020
Cited by 40 | Viewed by 8467
Abstract
Gram-negative bacteria have an outer membrane inhibiting the entry of antibiotics. Porins, found within the outer membrane, are involved in regulating the permeability of β-lactam antibiotics. β-lactamases are enzymes that are able to inactivate the antibacterial properties of β-lactam antibiotics. Interestingly, porins and [...] Read more.
Gram-negative bacteria have an outer membrane inhibiting the entry of antibiotics. Porins, found within the outer membrane, are involved in regulating the permeability of β-lactam antibiotics. β-lactamases are enzymes that are able to inactivate the antibacterial properties of β-lactam antibiotics. Interestingly, porins and β-lactamase are found in outer membrane vesicles (OMVs) of β-lactam-resistant Escherichia coli and may be involved in the survival of susceptible strains of E. coli in the presence of antibiotics, through the hydrolysis of the β-lactam antibiotic. In this study, OMVs isolated from β-lactam-resistant E. coli and from mutants, lacking porin or β-lactamase, were evaluated to establish if the porins or β-lactamase in OMVs were involved in the degradation of β-lactam antibiotics. OMVs isolated from E. coli deficient in β-lactamase did not show any degradation ability against β-lactam antibiotics, while OMVs lacking OmpC or OmpF showed significantly lower levels of hydrolyzing activity than OMVs from parent E. coli. These data reveal an important role of OMVs in bacterial defense mechanisms demonstrating that the OmpC and OmpF proteins allow permeation of β-lactam antibiotics into the lumen of OMVs, and antibiotics that enter the OMVs can be degraded by β-lactamase. Full article
Show Figures

Figure 1

Review

Jump to: Research

15 pages, 835 KiB  
Review
Host Immune Response and Novel Diagnostic Approach to NTM Infections
by Yuko Abe, Kiyoharu Fukushima, Yuki Hosono, Yuki Matsumoto, Daisuke Motooka, Naoko Ose, Shota Nakamura, Seigo Kitada, Hiroshi Kida and Atsushi Kumanogoh
Int. J. Mol. Sci. 2020, 21(12), 4351; https://doi.org/10.3390/ijms21124351 - 18 Jun 2020
Cited by 28 | Viewed by 6661
Abstract
The incidence and prevalence of non-tuberculous mycobacteria (NTM) infections are steadily increasing worldwide, partially due to the increased incidence of immunocompromised conditions, such as the post-transplantation state. The importance of proper diagnosis and management of NTM infection has been recently recognized. Host immunological [...] Read more.
The incidence and prevalence of non-tuberculous mycobacteria (NTM) infections are steadily increasing worldwide, partially due to the increased incidence of immunocompromised conditions, such as the post-transplantation state. The importance of proper diagnosis and management of NTM infection has been recently recognized. Host immunological responses play integral roles in vulnerability to NTM infections, and may contribute to the onset of specific types of NTM infection. Furthermore, distinct NTM species are known to affect and attenuate these host immune responses in unique manners. Therefore, host immune responses must be understood with respect to each causative NTM species. Here, we review innate, cellular-mediated, and humoral immunity to NTM and provide perspectives on novel diagnostic approaches regarding each NTM species. Full article
Show Figures

Figure 1

Back to TopTop