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Recent Research on Diabetes Mellitus and Its Complications, 3rd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (30 November 2024) | Viewed by 1247

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Guest Editor
Biosanitary Research Institute (IIB-VIU), Valencian International University (VIU), 46002 Valencia, Spain
Interests: diabetes and diabetes complication; cardiovascular; peripheral artery disease (PAD); critical limb ischemia pathology (CLI); regulatory standards; clinical trials; advanced therapies; advanced therapies medicinal products (ATMP); stem cells; good manufacturing practice (GMP); quality assurance (QA); quality control (QC); molecular and cellular biology; epigenetics; microRNAs
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Special Issue Information

Dear Colleagues,

Currently, the treatment for diabetes consists of treating hyperglycemia by providing exogenous insulin and a supply of medication or by islet cell transplantation. However, the inability to achieve tight control of glucose regulation has motivated more efforts to develop other approaches to address diabetes and reduce the burden of existing diabetes complications.

As volumes 1.0 and 2.0 of the Special Issue “Recent Research on Diabetes Mellitus and Its Complications” were successful, we therefore reopen this topic for volume 3.0 in the International Journal of Molecular Sciences (https://www.mdpi.com/journal/ijms; ISSN: 1422-0067; IF: 5.600; JCR Category Q1). This third Special Issue aims to publish priority studies clarifying the recent advances in understanding the biochemical cellular and molecular mechanisms causing diabetes and diabetic complications.

The topic is broad, being focused on molecular biology, and is intended to cover basic research related, but not limited to, the following:

Gene regulation (specific transcription factors, epigenetics, microRNAs, and non-coding RNAs).

https://www.mdpi.com/journal/ijms/special_issues/Diabetes_Mellitus_Complications

https://www.mdpi.com/journal/ijms/special_issues/Diabetes_Mellitus_Complications_2

Dr. Abdelkrim Hmadcha
Guest Editor

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Keywords

  • diabetes
  • diabetes complications
  • epigenetic
  • insulin resistance
  • metabolic pathways
  • glucose homeostasis
  • oxidative stress
  • β-cell

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Published Papers (1 paper)

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12 pages, 4398 KiB  
Article
Impacts of Hyperglycemia on Epigenetic Modifications in Human Gingival Fibroblasts and Gingiva in Diabetic Rats
by Kento Kojima, Nobuhisa Nakamura, Airi Hayashi, Shun Kondo, Megumi Miyabe, Takeshi Kikuchi, Noritaka Sawada, Tomokazu Saiki, Tomomi Minato, Reina Ozaki, Sachiko Sasajima, Akio Mitani and Keiko Naruse
Int. J. Mol. Sci. 2024, 25(20), 10979; https://doi.org/10.3390/ijms252010979 - 12 Oct 2024
Viewed by 1003
Abstract
Periodontal disease is considered one of the diabetic complications with high morbidity and severity. Recent studies demonstrated the involvement of the epigenome on diabetic complications. Histone modifications change chromatin architecture and gene activation. Histone modifications have been reported to alter chromatin structure and [...] Read more.
Periodontal disease is considered one of the diabetic complications with high morbidity and severity. Recent studies demonstrated the involvement of the epigenome on diabetic complications. Histone modifications change chromatin architecture and gene activation. Histone modifications have been reported to alter chromatin structure and regulate gene transcription. In this study, we investigated the impacts of H3 lysine 4 trimethylation (H3K4me3) and specific histone methyltransferases of H3K4 methylation, su(var)3-9, enhancer-of-zeste, and trithorax domain 1A (SETD1A) on periodontal tissue affected by the diabetic condition. We observed the increase in H3K4me3 and SETD1A in gingival tissue of diabetic rats compared with the normal rats. Cultured human fibroblasts (hGFs) confirmed a high glucose-induced increase in H3K4me3 and SETD1A. We further demonstrated that high glucose increased the gene expression of matrix metalloproteinase (MMP) 1 and MMP13, which were canceled by sinefungin, an SETD1A inhibitor. Our investigation suggests that diabetes triggers histone modifications in the gingival tissue, resulting in gingival inflammation. Histone modifications may play crucial roles in the development of periodontal disease in diabetes. Full article
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