mTOR in Metabolism and Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 20 April 2025 | Viewed by 6824
Special Issue Editor
Interests: cancer; metabolism; mRNA translation; mRNA degradation; mTOR
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mechanistic target of rapamycin (mTOR) integrates extracellular and intracellular signals (e.g., growth factors, insulin, nutrients, and oxygen) to stimulate anabolism, including protein and lipid synthesis, and bolster cellular growth and proliferation while suppressing autophagy. mTOR forms two distinct complexes, mTOR complex 1 (mTORC1) and 2 (mTORC2), which differ in their composition, downstream targets, regulation, and sensitivity to the naturally occurring allosteric mTOR inhibitor rapamycin. Dysregulation of the mTOR signaling pathway frequently accompanies diseases characterized by perturbations in energy metabolism and cell growth, such as cancer and metabolic syndrome. The first generation of mTOR inhibitors, rapamycin and its analogs, have been used for the treatment of several types of cancer with modest therapeutic effects. Chronic rapamycin significantly increases lifespan in model organisms with better health indicators. A new generation of ATP-competitive inhibitors that directly target the mTOR catalytic domain show potent and comprehensive inhibition and are currently being tested in clinics. The major clinical benefits of mTOR inhibition will likely be in the prevention or management of age-related diseases such as cancer and metabolic syndrome and its associated complications, resulting in late-life morbidity compression.
Continuing from the previous Issue, this Special Issue will cover a selection of recent research topics and current review articles in the field of the mTOR pathway and its impacts on metabolism and cancers.
Dr. Masahiro Morita
Guest Editor
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Keywords
- mTOR
- rapamycin
- inhibitor
- cancer
- metabolic syndrome
- aging
- mRNA translation
- 4E-BP
- S6K
- autophagy
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