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Lipid Signaling Pathways in Drug Delivery and Therapeutics
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Lipid Signaling Pathways in Drug Delivery and Therapeutics

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 4925

Special Issue Editor

Dr. Kin Sing Stephen Lee

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Guest Editor
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
Interests: polyunsaturated fatty acid metabolism; lipid signaling; bioorganic chemistry; medicinal chemistry; drug development; lipid mediator pharmacology; pharmacokinetic; assay development

Special Issue Information

Dear Colleagues,

Lipids, one of the basic building blocks of life, play a critical role in organismal physiology. Several classes of lipids and their downstream metabolites act as secondary messengers. These molecules interact with a variety of cellular targets including G-protein-coupled receptors, ion channels, nuclear receptors, kinases, etc. However, these endogenous lipids often have poor drug-like properties, since they are highly lipophilic with scarce water solubility, metabolically unstable, and poorly bioavailable. Therefore, it would be valuable to design novel molecules such as enzyme inhibitors that stabilize endogenous lipid mediators (e.g., ibuprofen) and mimics that act as agonists or antagonists of lipid signalling pathways. In addition, novel drug delivery systems could be developed to directly administer these specific molecules to target organs. In this Special Issue, we aim to present and discuss novel therapies targeting lipid signalling pathways.

Dr. Kin Sing Stephen Lee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • Lipid signalling molecules
  • Enzyme inhibitors
  • Agonist
  • Antagonist
  • Drug discovery and development
  • Drug design

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Published Papers (2 papers)

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Research

9 pages, 579 KiB  
Communication
An Update on Sphingosine-1-Phosphate and Lysophosphatidic Acid Receptor Transcripts in Rodent Olfactory Mucosa
by JT. Toebbe and Mary Beth Genter
Int. J. Mol. Sci. 2022, 23(8), 4343; https://doi.org/10.3390/ijms23084343 - 14 Apr 2022
Cited by 1 | Viewed by 1900
Abstract
Olfactory neurons connect the external environment and the brain, allowing the translocation of materials from the nasal cavity into the brain. The olfactory system is involved in SARS-CoV-2 infections; early in the pandemic declared in 2020, a loss of the sense of smell [...] Read more.
Olfactory neurons connect the external environment and the brain, allowing the translocation of materials from the nasal cavity into the brain. The olfactory system is involved in SARS-CoV-2 infections; early in the pandemic declared in 2020, a loss of the sense of smell was found in many infected patients. Attention has also been focused on the role that the olfactory epithelium appears to play in the entry of the SARS-CoV-2 virus into the brain. Specifically, SARS-CoV-2 enters cells via the angiotensin-converting enzyme 2 protein (ACE2), which is found on supporting cells in the olfactory epithelium. The intranasal administration of sphingosine has been proposed to prevent the binding of SARS-CoV-2 to ACE2. Further, sphingosine-1-phosphate (S1P) receptors appear to facilitate the entry of SARS-CoV-2 into the brain. The goal of these studies was to characterize S1P receptor expression status in rodent olfactory mucosa. The expression of receptors for a related sphingolipid, lysophosphatidic acid (LPA), was also assessed. The results confirm previous reports of S1P1 and S1P3 receptor expression, as well as LPA receptor 1, in mouse olfactory mucosa; moreover, they extend the previous findings to identify additional S1P and LPA receptor transcripts in rat and mouse olfactory mucosa, as well as in cultured olfactory neurons. These findings may enhance the utility of rodent models in identifying agonists and/or antagonists of S1P and LPA receptors that may block the entry of SARS-CoV-2 and other viruses into nasal epithelial cells, and prevent transmission from the nasal cavity into the brain. Full article
(This article belongs to the Special Issue Lipid Signaling Pathways in Drug Delivery and Therapeutics)
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17 pages, 2506 KiB  
Article
Fetal Zone Steroids and Estrogen Show Sex Specific Effects on Oligodendrocyte Precursor Cells in Response to Oxidative Damage
by Donna Elizabeth Sunny, Elke Hammer, Till Ittermann, Elisabeth Luise Krüger, Stephanie Hübner, Michaela Friederike Hartmann, Stefan Alexander Wudy, Uwe Völker and Matthias Heckmann
Int. J. Mol. Sci. 2021, 22(12), 6586; https://doi.org/10.3390/ijms22126586 - 19 Jun 2021
Cited by 6 | Viewed by 2468
Abstract
Oxygen causes white matter damage in preterm infants and male sex is a major risk factor for poor neurological outcome, which speculates the role of steroid hormones in sex-based differences. Preterm birth is accompanied by a drop in 17β-estradiol (E2) and progesterone along [...] Read more.
Oxygen causes white matter damage in preterm infants and male sex is a major risk factor for poor neurological outcome, which speculates the role of steroid hormones in sex-based differences. Preterm birth is accompanied by a drop in 17β-estradiol (E2) and progesterone along with increased levels of fetal zone steroids (FZS). We performed a sex-based analysis on the FZS concentration differences in urine samples collected from preterm and term infants. We show that, in preterm urine samples, the total concentration of FZS, and in particular the 16α-OH-DHEA concentration, is significantly higher in ill female infants as compared to males. Since we previously identified Nup133 as a novel target protein affected by hyperoxia, here we studied the effect of FZS, allopregnanolone (Allo) and E2 on differentiation and Nup133 signaling using mouse-derived primary oligodendrocyte progenitor cells (OPCs). We show that the steroids could reverse the effect of hyperoxia-mediated downregulation of Nup133 in cultured male OPCs. The addition of FZS and E2 protected cells from oxidative stress. However, E2, in presence of 16α-OH-DHEA, showed a negative effect on male cells. These results assert the importance of sex-based differences and their potential implications in preterm stress response. Full article
(This article belongs to the Special Issue Lipid Signaling Pathways in Drug Delivery and Therapeutics)
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