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Molecular Advances in Lymphoproliferative Diseases
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Molecular Advances in Lymphoproliferative Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (20 April 2023) | Viewed by 5394

Special Issue Editor

Dr. Gerardo Musuraca

E-Mail Website
Guest Editor
IRCCS - Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (I.R.S.T.) S.r.l., Via Piero Maroncelli, 40-47014 Meldola, FC, Italy
Interests: Lymphoma; Lymphoproliferative disorders; T Cells against cancer; Immunotherapies; Th17 in hematologic diseases

Special Issue Information

Dear Colleagues, 

Chronic Lymphoproliferative diseases are the most frequent haematological diseases in adults and despite the treatments currently in use, the percentages of patients who do not respond to treatment and die are still high. The immune system of these patients is often severely compromised by the chemotherapies used, but above all by the diseases themselves and yet little is known about what influences its permissiveness to the tumor and its escape.

In fact, the important role of immunotherapy and reactivation of the immune system is being re-understood, as a weapon to allow targeted treatment of the tumor and its constant immunocontrol until eradication.

This Special Issue aims to explore the correlations between chronic lymphoproliferative diseases and the immunological microenvironment, the immune system at the molecular and cellular level, its pathogenetic role and its therapeutic implications. Clinical studies with immunological/molecular aspects, experimental studies in in vitro and in vivo models, review articles as well, are all welcome for consideration.

Dr. Gerardo Musuraca
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lymphoma
  • T cell
  • immuntherapies
  • lymphoproliferative disease
  • myeloma

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Published Papers (2 papers)

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Research

17 pages, 5571 KiB  
Article
Follicular Lymphoma Microenvironment Traits Associated with Event-Free Survival
by Maria Maddalena Tumedei, Filippo Piccinini, Irene Azzali, Francesca Pirini, Sara Bravaccini, Serena De Matteis, Claudio Agostinelli, Gastone Castellani, Michele Zanoni, Michela Cortesi, Barbara Vergani, Biagio Eugenio Leone, Simona Righi, Anna Gazzola, Beatrice Casadei, Davide Gentilini, Luciano Calzari, Francesco Limarzi, Elena Sabattini, Andrea Pession, Marcella Tazzari and Clara Bertuzziadd Show full author list remove Hide full author list
Int. J. Mol. Sci. 2023, 24(12), 9909; https://doi.org/10.3390/ijms24129909 - 8 Jun 2023
Cited by 2 | Viewed by 2130
Abstract
The majority of patients with Follicular Lymphoma (FL) experience subsequent phases of remission and relapse, making the disease “virtually” incurable. To predict the outcome of FL patients at diagnosis, various clinical-based prognostic scores have been proposed; nonetheless, they continue to fail for a [...] Read more.
The majority of patients with Follicular Lymphoma (FL) experience subsequent phases of remission and relapse, making the disease “virtually” incurable. To predict the outcome of FL patients at diagnosis, various clinical-based prognostic scores have been proposed; nonetheless, they continue to fail for a subset of patients. Gene expression profiling has highlighted the pivotal role of the tumor microenvironment (TME) in the FL prognosis; nevertheless, there is still a need to standardize the assessment of immune-infiltrating cells for the prognostic classification of patients with early or late progressing disease. We studied a retrospective cohort of 49 FL lymph node biopsies at the time of the initial diagnosis using pathologist-guided analysis on whole slide images, and we characterized the immune repertoire for both quantity and distribution (intrafollicular, IF and extrafollicular, EF) of cell subsets in relation to clinical outcome. We looked for the natural killer (CD56), T lymphocyte (CD8, CD4, PD1) and macrophage (CD68, CD163, MA4A4A)-associated markers. High CD163/CD8 EF ratios and high CD56/MS4A4A EF ratios, according to Kaplan–Meier estimates were linked with shorter EFS (event-free survival), with the former being the only one associated with POD24. In contrast to IF CD68+ cells, which represent a more homogeneous population, higher in non-progressing patients, EF CD68+ macrophages did not stratify according to survival. We also identify distinctive MS4A4A+CD163-macrophage populations with different prognostic weights. Enlarging the macrophage characterization and combining it with a lymphoid marker in the rituximab era, in our opinion, may enable prognostic stratification for low-/high-grade FL patients beyond POD24. These findings warrant validation across larger FL cohorts. Full article
(This article belongs to the Special Issue Molecular Advances in Lymphoproliferative Diseases)
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15 pages, 4447 KiB  
Article
Reduced Percentage of CD14dimCD16+SLAN+ Monocytes Producing TNF and IL-12 as an Immunological Sign of CLL Progression
by Wioleta Kowalska, Michał Zarobkiewicz, Waldemar Tomczak, Justyna Woś, Izabela Morawska and Agnieszka Bojarska-Junak
Int. J. Mol. Sci. 2022, 23(6), 3029; https://doi.org/10.3390/ijms23063029 - 11 Mar 2022
Cited by 5 | Viewed by 2656
Abstract
Monocytes are one of the least studied immune cells with a potentially important role in the pathogenesis of chronic lymphocytic leukemia (CLL). Nevertheless, data regarding the role of subpopulations of monocytes in the CLL microenvironment are still limited. For the very first time, [...] Read more.
Monocytes are one of the least studied immune cells with a potentially important role in the pathogenesis of chronic lymphocytic leukemia (CLL). Nevertheless, data regarding the role of subpopulations of monocytes in the CLL microenvironment are still limited. For the very first time, this study presents an assessment of monocyte subsets divided according to SLAN and CD16 expression in CLL patients. The study involved 70 freshly diagnosed CLL patients and 35 healthy donors. Using flow cytometry, monocyte subpopulations were assessed among PBMCs. CD14+ monocytes can be divided into: “classical” (CD14+CD16−SLAN−), “intermediate” (CD14+CD16+SLAN−) and “non-classical” (CD14dimCD16+SLAN+). In our study, we noted an increased percentage of non-classical monocytes with intracellular expression of TNF and IL-12. On the other hand, among the intermediate monocytes, a significantly higher percentage of cells synthesizing anti-inflammatory IL-10 was detected. The percentage of CD14dimCD16+SLAN+ monocytes producing TNF and IL-12 decreased with the stage of CLL and inversely correlated with the expression of the prognostic factors ZAP-70 and CD38. Moreover, the percentage of CD14dimCD16+SLAN+ monocytes producing TNF and IL-12 was lower in CLL patients requiring treatment. This may indicate the beneficial effect of non-classical monocytes on the anti-tumor response. Full article
(This article belongs to the Special Issue Molecular Advances in Lymphoproliferative Diseases)
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