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Genetic and Epigenetic Influences on Personality Traits and Athletic Performance

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 20 July 2025 | Viewed by 3802

Special Issue Editor


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Guest Editor
Faculty of Physical Education, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland
Interests: human and sport genetic; psychogenetic determinants of physical activity; exercise-induced muscle damage and inflammation; influence of physical activity on intestinal microbiota in athletes; molecular background of exercise-induced adaptation

Special Issue Information

Dear Colleagues,

Understanding the interplay between genetics, epigenetics, and human behavior is critical to advancing our knowledge of personality traits and athletic performance. A complex web of genetic predispositions, epigenetic modifications, and environmental factors shapes these traits and abilities. This Special Issue explores these intricate relationships and sheds light on how genetic and epigenetic factors influence personality development and athletic performance.

Recent advances in genomic and epigenomic research have shown that genetic factors significantly influence athletic performance and personality traits. However, these traits are not controlled by single genes but by multiple genetic loci, each contributing modestly to the overall phenotype. The role of gene-gene interactions (epistasis) and gene-environment interactions further complicates this genetic landscape. In addition, epigenetic mechanisms, which regulate gene expression without altering the DNA sequence, play a central role in modulating these traits in response to environmental stimuli such as exercise, diet, and psychological stress.

This Special Issue aims to bring together cutting-edge research that explores the genetic and epigenetic underpinnings of personality traits and athletic performance. We encourage submissions that employ advanced methodologies, including genome-wide association studies (GWAS), epigenome-wide association studies (EWAS), and other approaches that explore genetic, epigenetic, and environmental data. Research exploring the genetic predispositions contributing to athletic excellence and the epigenetic and microbiota changes associated with physical training will be particularly relevant.

This Special Issue integrates insights from genetics, epigenetics, psychology, microbiota, and exercise science to advance our understanding of the biological underpinnings of personality and athletic performance. We hope that the presented findings will pave the way for personalized approaches to psychological assessment, athletic training, and human potential enhancement.

This Special Issue is supervised by Dr. Kinga Humińska-Lisowska, assisted by our Topical Advisory Panel Member Dr. Aleksandra Bojarczuk (Gdansk University of Physical Education and Sport, Poland).

Dr. Kinga Huminska-Lisowska
Guest Editor

Manuscript Submission Information

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Keywords

  • genetics
  • epigenetics
  • personality traits
  • athletic performance
  • polymorphisms
  • microbiome
  • neurotransmitters
  • molecular mechanisms
  • metabolic health
  • injury susceptibility

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Published Papers (1 paper)

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Review

50 pages, 636 KiB  
Review
Dopamine in Sports: A Narrative Review on the Genetic and Epigenetic Factors Shaping Personality and Athletic Performance
by Kinga Humińska-Lisowska
Int. J. Mol. Sci. 2024, 25(21), 11602; https://doi.org/10.3390/ijms252111602 - 29 Oct 2024
Cited by 1 | Viewed by 3258
Abstract
This narrative review examines the relationship between dopamine-related genetic polymorphisms, personality traits, and athletic success. Advances in sports genetics have identified specific single nucleotide polymorphisms (SNPs) in dopamine-related genes linked to personality traits crucial for athletic performance, such as motivation, cognitive function, and [...] Read more.
This narrative review examines the relationship between dopamine-related genetic polymorphisms, personality traits, and athletic success. Advances in sports genetics have identified specific single nucleotide polymorphisms (SNPs) in dopamine-related genes linked to personality traits crucial for athletic performance, such as motivation, cognitive function, and emotional resilience. This review clarifies how genetic variations can influence athletic predisposition through dopaminergic pathways and environmental interactions. Key findings reveal associations between specific SNPs and enhanced performance in various sports. For example, polymorphisms such as COMT Val158Met rs4680 and BDNF Val66Met rs6265 are associated with traits that could benefit performance, such as increased focus, stress resilience and conscientiousness, especially in martial arts. DRD3 rs167771 is associated with higher agreeableness, benefiting teamwork in sports like football. This synthesis underscores the multidimensional role of genetics in shaping athletic ability and advocates for integrating genetic profiling into personalized training to optimize performance and well-being. However, research gaps remain, including the need for standardized training protocols and exploring gene–environment interactions in diverse populations. Future studies should focus on how genetic and epigenetic factors can inform tailored interventions to enhance both physical and psychological aspects of athletic performance. By bridging genetics, personality psychology, and exercise science, this review paves the way for innovative training and performance optimization strategies. Full article
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