Purine Nucleotides Metabolism and Signaling in Human Diseases: Search for a Target for Novel Therapies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 4485
Special Issue Editor
Special Issue Information
Dear Colleagues,
Among purine nucleotides metabolism, the cyclic AMP (cAMP) discovered as the “second messenger”, was first investigated as the main contributor of intracellular signaling, as explored by the 1971 Nobel Prize in Physiology or Medicine recipient Earl W. Sutherland, Jr. Later, research was conducted for cGMP by 1998 Nobel Prize recipients, Robert F. Furchgott, Louis J. Ignarro and Ferid Murad. Currently, the development of molecular biology allows us to investigate and classify the superfamily of cyclic nucleotide phosphodiesterases. They specifically control cyclic nucleotides levels at different cellular levels, hydrolyzing cyclic nucleotides in their respective nucleotide monophosphates, which can modulate cellular signaling cascade.
Our knowledge of intracellular signaling regulation drastically increased during the last fifty years opening the development of multiple signaling pathways, issued from purine nucleotides.
In the present Special Issue, it would be of interest to consider not only part of the specific molecular regulations of signaling, but to consider the whole signalosome, determining links inside the regulatory cascade and purine nucleotides mechanisms in normal and pathological states in humans, in order to develop new therapeutic approaches.
Prof. Dr. Claire Lugnier
Guest Editor
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Keywords
- cAMP
- cGMP
- AMP
- GMP
- PKA
- PKG
- CREB
- cyclic nucleotide phosphodiesterase (PDE1-PDE11)
- AMPkinase
- MAPkinase
- mRNA
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