Micro and Nanosystems for Drug Delivery
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: closed (30 December 2023) | Viewed by 12942
Special Issue Editors
2. Interdepartmental Centre for Innovation in Health Products Biopharmanet-TEC, University of Parma, Parco Area delle Scienze 27/a, Parma, Italy
Interests: polymers; drug delivery; biopharmaceuticals; in vitro models
Special Issues, Collections and Topics in MDPI journals
Interests: drug delivery; cancer therapy; anti-viral formulations; curcumin formulations; inorganic nano-hybrids
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Formulation is known as the ‘Cinderella’ of drug development, often regarded as playing a secondary role in the success of a medicinal product. On the contrary, drug delivery is essential in overcoming challenges in the administration of therapeutics, whose efficacy is sometimes limited by the physico-chemical characteristics of the active substance. Drug solubility and drug absorption are indispensable for successful therapy, both for small chemical entities and for the members of the fast-growing field of biopharmaceutical products. Micro- and nano-systems provide the opportunity to positively modify the fate of a drug in an organism by improving its bioavailability and biodistribution, stability, efficacy and specificity. Size is the key element that determines the unique performances of these innovative drug delivery systems, whatever is the intended route of administration. Due to the inborn interdisciplinarity and the variety of the methods proposed to produce micro- and nano-systems, the number of publications about this topic has reached an impressive number, spanning, among many disciplines, from pharmacy to tissue engineering, and is bound to increase. In addition, demonstration of therapeutic efficacy of these systems is sometimes elusive. Some order is needed, in particular with respect to the correlation between the physico-chemical features of these structures and their performances as a delivery system. This Special Issue aims to focus on models of micro and nano drug delivery systems, intended for different routes of administration, with specific emphasis on their biological fate and their ability to interact with biological targets. This is a mandatory step in the pipeline to the approval of these systems as medicinal products.
Dr. Annalisa Bianchera
Dr. N. Sanoj Rejinold
Guest Editors
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Keywords
- microparticles
- nanoparticles
- biopharmaceuticals
- drug delivery
- drug targeting
- absorption
- particle internalization
- endocytosis
- mucoadhesion
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