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Recent Advances on Multifunctional Bioscaffolds
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Recent Advances on Multifunctional Bioscaffolds

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 3854

Special Issue Editor

Prof. Dr. Antonio Apicella

E-Mail Website
Guest Editor
Advanced Material Laboratory, Department of Architecture and Industrial Design, University of Campania, Luigi Vanvitelli, 81031 Aversa, Italy
Interests: smart biomaterials for tissue engineering; ceramo-polymeric hybrid systems; hybrid smart structures; new theoretical approaches for biomimetic material and prostheses
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Bone tissue engineering is a complex and dynamic bone remodelling process that requires the recruitment of osteoprogenitor cells, their proliferation, differentiation, and matrix formation. Innovative bone scaffolds could provide the mechanical support during the repair and regeneration of damaged or diseased bones, ensuring suitable biomechanical and biochemical environments.

Complex bone biomechanics require the use of tissue engineering scaffolding systems with strict material and structural requirements that are able to support normal cellular activity, including molecular signalling systems without toxic effects, in order to match host bone properties for adequate load transfer and bone stimulus.

The present Special Issue will consider today’s key challenges regarding their successful implementation in bone tissue engineering, including, but not limited to, the use of targeted biomolecules, mechanical properties, multi-scale porous scaffolds involving both micro and macro porosities, new structural bioresorbable scaffolds at controlled resorption rates, and engineering aspects such as design and 3D-additive fabrication techniques.

Prof. Dr. Antonio Apicella
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bone tissue engineering
  • biomechanically active scaffolds
  • metal additive scaffold manufacturing
  • structural bioresorbable materials
  • multiscale porous scaffolds
  • targeted biomolecules release
  • bioactive coatings and membranes

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Published Papers (2 papers)

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Research

11 pages, 1734 KiB  
Communication
Role of Polymer Concentration on the Release Rates of Proteins from Single- and Double-Network Hydrogels
by Daryn Browne, Francesca Briggs and Prashanth Asuri
Int. J. Mol. Sci. 2023, 24(23), 16970; https://doi.org/10.3390/ijms242316970 - 30 Nov 2023
Cited by 1 | Viewed by 902
Abstract
Controlled delivery of proteins has immense potential for the treatment of various human diseases, but effective strategies for their delivery are required before this potential can be fully realized. Recent research has identified hydrogels as a promising option for the controlled delivery of [...] Read more.
Controlled delivery of proteins has immense potential for the treatment of various human diseases, but effective strategies for their delivery are required before this potential can be fully realized. Recent research has identified hydrogels as a promising option for the controlled delivery of therapeutic proteins, owing to their ability to respond to diverse chemical and biological stimuli, as well as their customizable properties that allow for desired delivery rates. This study utilized alginate and chitosan as model polymers to investigate the effects of hydrogel properties on protein release rates. The results demonstrated that polymer properties, concentration, and crosslinking density, as well as their responses to pH, can be tailored to regulate protein release rates. The study also revealed that hydrogels may be combined to create double-network hydrogels to provide an additional metric to control protein release rates. Furthermore, the hydrogel scaffolds were also found to preserve the long-term function and structure of encapsulated proteins before their release from the hydrogels. In conclusion, this research demonstrates the significance of integrating porosity and response to stimuli as orthogonal control parameters when designing hydrogel-based scaffolds for therapeutic protein release. Full article
(This article belongs to the Special Issue Recent Advances on Multifunctional Bioscaffolds)
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15 pages, 13630 KiB  
Article
Design, Characterization, and Antibacterial Performance of MAPLE-Deposited Coatings of Magnesium Phosphate-Containing Silver Nanoparticles in Biocompatible Concentrations
by Denisa Alexandra Florea, Valentina Grumezescu, Alexandra Cătălina Bîrcă, Bogdan Ștefan Vasile, Mihaela Mușat, Cristina Chircov, Miruna S. Stan, Alexandru Mihai Grumezescu, Ecaterina Andronescu and Mariana Carmen Chifiriuc
Int. J. Mol. Sci. 2022, 23(14), 7910; https://doi.org/10.3390/ijms23147910 - 18 Jul 2022
Cited by 10 | Viewed by 2238
Abstract
Bone disorders and traumas represent a common type of healthcare emergency affecting men and women worldwide. Since most of these diseases imply surgery, frequently complicated by exogenous or endogenous infections, there is an acute need for improving their therapeutic approaches, particularly in clinical [...] Read more.
Bone disorders and traumas represent a common type of healthcare emergency affecting men and women worldwide. Since most of these diseases imply surgery, frequently complicated by exogenous or endogenous infections, there is an acute need for improving their therapeutic approaches, particularly in clinical conditions requiring orthopedic implants. Various biomaterials have been investigated in the last decades for their potential to increase bone regeneration and prevent orthopedic infections. The present study aimed to develop a series of MAPLE-deposited coatings composed of magnesium phosphate (Mg3(PO4)2) and silver nanoparticles (AgNPs) designed to ensure osteoblast proliferation and anti-infective properties simultaneously. Mg3(PO4)2 and AgNPs were obtained through the cooling bath reaction and chemical reduction, respectively, and then characterized through X-ray Diffraction (XRD), Transmission Electron Microscopy (TEM), and Selected Area Electron Diffraction (SAED). Subsequently, the obtained coatings were evaluated by Infrared Microscopy (IRM), Fourier-Transform Infrared Spectroscopy (FT-IR), and Scanning Electron Microscopy (SEM). Their biological properties show that the proposed composite coatings exhibit well-balanced biocompatibility and antibacterial activity, promoting osteoblasts viability and proliferation and inhibiting the adherence and growth of Staphylococcus aureus and Pseudomonas aeruginosa, two of the most important agents of orthopedic implant-associated infections. Full article
(This article belongs to the Special Issue Recent Advances on Multifunctional Bioscaffolds)
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