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Non-thermal Plasma Interactions with Different Living Systems
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Non-thermal Plasma Interactions with Different Living Systems

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biophysics".

Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 19510

Special Issue Editor

Dr. Eva Horvathova

E-Mail Website
Guest Editor
Cancer Research Institute, Biomedical Research Centre of the Slovak Academy of Sciences, Dúbravská Cesta 9, 845 05 Bratislava, Slovakia
Interests: bioctive compounds; secondary metabolites; structure-activity relationship; DNA damage detection; oxidative stress; non-thermal plasma
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

For optimal and broad use of modern technologies in human life, it is necessary to know the molecular mechanisms of their interactions with biological materials. Among these technologies, non-thermal plasma (NTP) and its impacts on different biological systems have begun to be more extensively studied in the past few decades. Its decontamination effects are the most significant and most studied. Plasma can effectively inactivate a broad range of microorganisms, which predetermines it for many practical applications in the agriculture and food industry. The positive impact of NTP has been confirmed in medicine, especially, in dermatology and oncology. Besides this, NTP can also degrade various pharmaceuticals from wastewater or the environment.

This Special Issue will bring together original research and review articles on non-thermal plasma interactions with various living systems. It highlights discoveries, comprehensive approaches, and developments in molecular research on the utilization of this physical factor in different fields of human life. The main feature of this Special Issue is to provide open-source sharing of significant works in the field of molecular research that can advance our understanding of plasma action, which may lead to the genotoxicological safety in all mentioned applications.

Topics of this Special Issue include, but are not limited to the following:

  • Plasma–cell and plasma–tissue interactions – biological and biochemical reactions
  • Plasma–surface interactions/modifications for biomedical applications
  • Plasma-based decontamination and sterilization
  • Plasma medical applications – clinical and animal studies
  • Plasma for pharmaceutical applications; biochemical, and biomolecular engineering
  • Agricultural and food applications of plasma
  • Plasma-activated liquids for biological applications
  • Plasma-induced damage of biomacromolecules

Dr. Eva Horvathova
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • Non-thermal plasma
  • Molecular mechanisms of plasma action
  • Reactive oxygen and nitrogen species
  • Charged particles
  • Plasma decontamination
  • Plasma medicine
  • Plasma agriculture
  • Plasma activated water
  • Plasma activated medium
  • Oxidative stress
  • Plasma source
  • Plasma genotoxicity
  • Plasma and biomacromolecules interactions
  • Plasma pharmaceuticals degradation
  • Plasma interactions
  • Plasma treatment

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Published Papers (5 papers)

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Research

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20 pages, 3142 KiB  
Article
Toxicity Assessment of Long-Term Exposure to Non-Thermal Plasma Activated Water in Mice
by Valentin Nastasa, Aurelian-Sorin Pasca, Razvan-Nicolae Malancus, Andra-Cristina Bostanaru, Luminita-Iuliana Ailincai, Elena-Laura Ursu, Ana-Lavinia Vasiliu, Bogdan Minea, Eugen Hnatiuc and Mihai Mares
Int. J. Mol. Sci. 2021, 22(21), 11534; https://doi.org/10.3390/ijms222111534 - 26 Oct 2021
Cited by 28 | Viewed by 3226
Abstract
Non-thermal plasma activated water (PAW) has recently emerged as a powerful antimicrobial agent. Despite numerous potential bio-medical applications, studies concerning toxicity in live animals, especially after long-term exposure, are scarce. Our study aimed to assess the effects of long-term watering with PAW on [...] Read more.
Non-thermal plasma activated water (PAW) has recently emerged as a powerful antimicrobial agent. Despite numerous potential bio-medical applications, studies concerning toxicity in live animals, especially after long-term exposure, are scarce. Our study aimed to assess the effects of long-term watering with PAW on the health of CD1 mice. PAW was prepared from distilled water with a GlidArc reactor according to a previously published protocol. The pH was 2.78. The mice received PAW (experimental group) or tap water (control group) daily for 90 days as the sole water source. After 90 days, the following investigations were performed on the euthanatized animals: gross necropsy, teeth mineral composition, histopathology, immunohistochemistry, hematology, blood biochemistry, methemoglobin level and cytokine profile. Mice tolerated PAW very well and no adverse effects were observed during the entire period of the experiment. Histopathological examination of the organs and tissues did not reveal any structural changes. Moreover, the expression of proliferation markers PCNA and Ki67 has not been identified in the epithelium of the upper digestive tract, indicating the absence of any pre- or neoplastic transformations. The results of our study demonstrated that long-term exposure to PAW caused no toxic effects and could be used as oral antiseptic solution in dental medicine. Full article
(This article belongs to the Special Issue Non-thermal Plasma Interactions with Different Living Systems)
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22 pages, 2000 KiB  
Article
Canady Helios Cold Plasma Induces Breast Cancer Cell Death by Oxidation of Histone mRNA
by Xiaoqian Cheng, Saravana R. K. Murthy, Taisen Zhuang, Lawan Ly, Olivia Jones, Giacomo Basadonna, Michael Keidar, Yasmine Kanaan and Jerome Canady
Int. J. Mol. Sci. 2021, 22(17), 9578; https://doi.org/10.3390/ijms22179578 - 3 Sep 2021
Cited by 14 | Viewed by 3377
Abstract
Breast cancer is the most common cancer among women worldwide. Its molecular receptor marker status and mutational subtypes complicate clinical therapies. Cold atmospheric plasma is a promising adjuvant therapy to selectively combat many cancers, including breast cancer, but not normal tissue; however, the [...] Read more.
Breast cancer is the most common cancer among women worldwide. Its molecular receptor marker status and mutational subtypes complicate clinical therapies. Cold atmospheric plasma is a promising adjuvant therapy to selectively combat many cancers, including breast cancer, but not normal tissue; however, the underlying mechanisms remain unexplored. Here, four breast cancer cell lines with different marker status were treated with Canady Helios Cold Plasma™ (CHCP) at various dosages and their differential progress of apoptosis was monitored. Inhibition of cell proliferation, induction of apoptosis, and disruption of the cell cycle were observed. At least 16 histone mRNA types were oxidized and degraded immediately after CHCP treatment by 8-oxoguanine (8-oxoG) modification. The expression of DNA damage response genes was up-regulated 12 h post-treatment, indicating that 8-oxoG modification and degradation of histone mRNA during the early S phase of the cell cycle, rather than DNA damage, is the primary cause of cancer cell death induced by CHCP. Our report demonstrates for the first time that CHCP effectively induces cell death in breast cancer regardless of subtyping, through histone mRNA oxidation and degradation during the early S phase of the cell cycle. Full article
(This article belongs to the Special Issue Non-thermal Plasma Interactions with Different Living Systems)
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17 pages, 519 KiB  
Article
The Effect of Non-Thermal Plasma on the Structural and Functional Characteristics of Human Spermatozoa
by Eva Tvrdá, Daniel Lovíšek, Stanislav Kyzek, Dušan Kováčik and Eliška Gálová
Int. J. Mol. Sci. 2021, 22(9), 4979; https://doi.org/10.3390/ijms22094979 - 7 May 2021
Cited by 4 | Viewed by 2331
Abstract
Significant antibacterial properties of non-thermal plasma (NTP) have converted this technology into a promising alternative to the widespread use of antibiotics in assisted reproduction. As substantial data available on the specific in vitro effects of NTP on male reproductive cells are currently missing, [...] Read more.
Significant antibacterial properties of non-thermal plasma (NTP) have converted this technology into a promising alternative to the widespread use of antibiotics in assisted reproduction. As substantial data available on the specific in vitro effects of NTP on male reproductive cells are currently missing, this study was designed to investigate selected quality parameters of human spermatozoa (n = 51) exposed to diffuse coplanar surface barrier discharge NTP for 0 s, 15 s, 30 s, 60 s and 90 s. Sperm motility characteristics, membrane integrity, mitochondrial activity, production of reactive oxygen species (ROS), DNA fragmentation and lipid peroxidation (LPO) were investigated immediately following exposure to NTP and 2 h post-NTP treatment. Exposure to NTP with a power input of 40 W for 15 s or 30 s was found to have no negative effects on the sperm structure or function. However, a prolonged NTP treatment impaired all the sperm quality markers in a time- and dose-dependent manner. The most likely mechanism of action of high NTP doses may be connected to ROS overproduction, leading to plasma membrane destabilization, LPO, mitochondrial failure and a subsequent loss of motility as well as DNA integrity. As such, our findings indicate that appropriate plasma exposure conditions need to be carefully selected in order to preserve the sperm vitality, should NTP be used in the practical management of bacteriospermia in the future. Full article
(This article belongs to the Special Issue Non-thermal Plasma Interactions with Different Living Systems)
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Review

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15 pages, 1026 KiB  
Review
Effects of Non-Thermal Plasma on Yeast Saccharomyces cerevisiae
by Peter Polčic and Zdenko Machala
Int. J. Mol. Sci. 2021, 22(5), 2247; https://doi.org/10.3390/ijms22052247 - 24 Feb 2021
Cited by 16 | Viewed by 3552
Abstract
Cold plasmas generated by various electrical discharges can affect cell physiology or induce cell damage that may often result in the loss of viability. Many cold plasma-based technologies have emerged in recent years that are aimed at manipulating the cells within various environments [...] Read more.
Cold plasmas generated by various electrical discharges can affect cell physiology or induce cell damage that may often result in the loss of viability. Many cold plasma-based technologies have emerged in recent years that are aimed at manipulating the cells within various environments or tissues. These include inactivation of microorganisms for the purpose of sterilization, food processing, induction of seeds germination, but also the treatment of cells in the therapy. Mechanisms that underlie the plasma-cell interactions are, however, still poorly understood. Dissection of cellular pathways or structures affected by plasma using simple eukaryotic models is therefore desirable. Yeast Saccharomyces cerevisiae is a traditional model organism with unprecedented impact on our knowledge of processes in eukaryotic cells. As such, it had been also employed in studies of plasma-cell interactions. This review focuses on the effects of cold plasma on yeast cells. Full article
(This article belongs to the Special Issue Non-thermal Plasma Interactions with Different Living Systems)
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16 pages, 1066 KiB  
Review
Non-Thermal Plasma—A New Green Priming Agent for Plants?
by Ľudmila Holubová, Stanislav Kyzek, Ivana Ďurovcová, Jana Fabová, Eva Horváthová, Andrea Ševčovičová and Eliška Gálová
Int. J. Mol. Sci. 2020, 21(24), 9466; https://doi.org/10.3390/ijms21249466 - 12 Dec 2020
Cited by 55 | Viewed by 6158
Abstract
Since the earliest agricultural attempts, humankind has been trying to improve crop quality and yields, as well as protect them from adverse conditions. Strategies to meet these goals include breeding, the use of fertilisers, and the genetic manipulation of crops, but also an [...] Read more.
Since the earliest agricultural attempts, humankind has been trying to improve crop quality and yields, as well as protect them from adverse conditions. Strategies to meet these goals include breeding, the use of fertilisers, and the genetic manipulation of crops, but also an interesting phenomenon called priming or adaptive response. Priming is based on an application of mild stress to prime a plant for another, mostly stronger stress. There are many priming techniques, such as osmopriming, halopriming, or using physical agents. Non-thermal plasma (NTP) represents a physical agent that contains a mixture of charged, neutral, and radical (mostly reactive oxygen and nitrogen species) particles, and can cause oxidative stress or even the death of cells or organisms upon interaction. However, under certain conditions, NTP can have the opposite effect, which has been previously documented for many plant species. Seed surface sterilization and growth enhancement are the most-reported positive effects of NTP on plants. Moreover, some studies suggest the role of NTP as a promising priming agent. This review deals with the effects of NTP treatment on plants from interaction with seed and cell surface, influence on cellular molecular processes, up to the adaptive response caused by NTP. Full article
(This article belongs to the Special Issue Non-thermal Plasma Interactions with Different Living Systems)
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