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Targeted Radioligand Therapy and Immunotherapy for Cancer Treatment

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 20 February 2025 | Viewed by 2086

Special Issue Editors

Departments of Radiology, Chemistry, Institute of Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI 48824, USA
Interests: oncology; radioactivity; cancer treatment

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Guest Editor
Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA
Interests: radiopharmaceutical therapy; radiochemistry; tumor microenvironment; tumor immunology; precision oncology; molecular targeting; molecular imaging; radiopharmaceuticals; targeted therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are delighted to announce a call for submissions for this Special Issue of the International Journal of Molecular Sciences. This Special Issue aims to explore the latest developments, challenges and innovations at the intersection of targeted radioligand therapy and immunotherapy as potent modalities for cancer treatment.

Targeted radioligand therapy and immunotherapy have emerged as transformative approaches within the oncological landscape, offering new avenues for personalized and effective cancer treatment. The combination of these modalities holds significant promise in enhancing treatment outcomes, overcoming resistance mechanisms and improving patient survival rates.

We welcome original research articles, reviews, clinical studies, case reports and perspectives addressing various aspects of targeted radioligand therapy and immunotherapy in cancer treatment, including but not limited to, the following:

  1. Mechanisms of action and biological interactions between targeted radioligand therapy and immunotherapy;
  2. Preclinical and clinical efficacy of combined targeted radioligand therapy and immunotherapy in different cancer types;
  3. Radiobiology and immunobiology of the tumor microenvironment in the context of combined therapy;
  4. Novel strategies for optimizing the combination of targeted radioligand therapy and immunotherapy;
  5. Novel biomarkers and prediction of response to combined therapy;
  6. Technological advancements and innovations in targeted radioligand therapy and immunotherapy delivery;
  7. Immunotherapy-based approaches for overcoming resistance to targeted radioligand therapy;
  8. Radiomics and immunogenomics in predicting treatment response and patient outcomes;
  9. Challenges and future directions in the clinical integration of targeted radioligand therapy and immunotherapy.

Dr. Jinda Fan
Dr. Carolina de Aguiar Ferreira
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • targeted radioligand therapy
  • immunotherapy
  • receptor targeting
  • tumor-specific antigens
  • immune checkpoint inhibitors
  • radiosensitization
  • tumor microenvironment
  • combination therapy

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Published Papers (1 paper)

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Review

28 pages, 2922 KiB  
Review
EGFR- and Integrin αVβ3-Targeting Peptides as Potential Radiometal-Labeled Radiopharmaceuticals for Cancer Theranostics
by Cibele Rodrigues Toledo, Ahmed A. Tantawy, Leonardo Lima Fuscaldi, Luciana Malavolta and Carolina de Aguiar Ferreira
Int. J. Mol. Sci. 2024, 25(15), 8553; https://doi.org/10.3390/ijms25158553 - 5 Aug 2024
Viewed by 1517
Abstract
The burgeoning field of cancer theranostics has witnessed advancements through the development of targeted molecular agents, particularly peptides. These agents exploit the overexpression or mutations of specific receptors, such as the Epidermal Growth Factor receptor (EGFR) and αVβ3 integrin, which [...] Read more.
The burgeoning field of cancer theranostics has witnessed advancements through the development of targeted molecular agents, particularly peptides. These agents exploit the overexpression or mutations of specific receptors, such as the Epidermal Growth Factor receptor (EGFR) and αVβ3 integrin, which are pivotal in tumor growth, angiogenesis, and metastasis. Despite the extensive research into and promising outcomes associated with antibody-based therapies, peptides offer a compelling alternative due to their smaller size, ease of modification, and rapid bioavailability, factors which potentially enhance tumor penetration and reduce systemic toxicity. However, the application of peptides in clinical settings has challenges. Their lower binding affinity and rapid clearance from the bloodstream compared to antibodies often limit their therapeutic efficacy and diagnostic accuracy. This overview sets the stage for a comprehensive review of the current research landscape as it relates to EGFR- and integrin αVβ3-targeting peptides. We aim to delve into their synthesis, radiolabeling techniques, and preclinical and clinical evaluations, highlighting their potential and limitations in cancer theranostics. This review not only synthesizes the extant literature to outline the advancements in peptide-based agents targeting EGFR and integrin αVβ3 but also identifies critical gaps that could inform future research directions. By addressing these gaps, we contribute to the broader discourse on enhancing the diagnostic precision and therapeutic outcomes of cancer treatments. Full article
(This article belongs to the Special Issue Targeted Radioligand Therapy and Immunotherapy for Cancer Treatment)
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