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Mechanisms of Immune Tolerance and Autoimmune Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 20 May 2025 | Viewed by 5489

Special Issue Editors


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Guest Editor
1. Institute for Research Marqués de Valdecilla (IDIVAL), 39011 Santander, Spain
2. Immunology Department, Marqués de Valdecilla University Hospital, 39008 Santander, Spain
3. Molecular Biology Department, University of Cantabria, 39011 Santander, Spain
4. National Microbiology Center, National Institute of Health Carlos III, 28220 Madrid, Spain
5. Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Interests: immunology; autoimmunity; transplantation; tolerance; human pathology; biomarkers
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Guest Editor
Instituto de Salud Carlos III, Majadahonda, 28029 Madrid, Spain
Interests: trained immunity; immune tolerance; organ transplantation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The field of immunological tolerance and the induction of autoimmune diseases has started focusing on the role of the adaptative immune response and how the failure of central and peripheral tolerance could induce autoimmunity. In the last decade, increasing attention has been paid to the ways in which innate immunity and the cellular participants in inflammation might be implicated in these diseases. Therefore, several new autoinflammatory diseases have been described using the genetic data associated with functional consequences. Through the study of the genetic, phenotypic, metabolic and functional mechanisms involved in these immune-mediated diseases, novel diagnostic and therapeutic approaches have been developed. Furthermore, there is continuum with no clear border between autoinflammatory and autoimmune disease. This Special Issue specifically welcomes the submission of studies that focus on the basic mechanisms underlying the production of autoimmune and autoinflammatory diseases, in addition to translational studies.

Prof. Dr. Marcos López Hoyos
Dr. Jordi Ochando
Guest Editors

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Keywords

  • immunological tolerance
  • autoimmune diseases
  • autoinflammatory diseases
  • inflammation
  • immune-mediated diseases

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Published Papers (1 paper)

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Review

29 pages, 1678 KiB  
Review
Understanding Autoimmunity: Mechanisms, Predisposing Factors, and Cytokine Therapies
by Farzana Yasmeen, Rameez Hassan Pirzada, Bilal Ahmad, Bogeum Choi and Sangdun Choi
Int. J. Mol. Sci. 2024, 25(14), 7666; https://doi.org/10.3390/ijms25147666 - 12 Jul 2024
Cited by 1 | Viewed by 5062
Abstract
Autoimmunity refers to an organism’s immune response against its own healthy cells, tissues, or components, potentially leading to irreversible damage to vital organs. Central and peripheral tolerance mechanisms play crucial roles in preventing autoimmunity by eliminating self-reactive T and B cells. The disruption [...] Read more.
Autoimmunity refers to an organism’s immune response against its own healthy cells, tissues, or components, potentially leading to irreversible damage to vital organs. Central and peripheral tolerance mechanisms play crucial roles in preventing autoimmunity by eliminating self-reactive T and B cells. The disruption of immunological tolerance, characterized by the failure of these mechanisms, results in the aberrant activation of autoreactive lymphocytes that target self-tissues, culminating in the pathogenesis of autoimmune disorders. Genetic predispositions, environmental exposures, and immunoregulatory disturbances synergistically contribute to the susceptibility and initiation of autoimmune pathologies. Within the realm of immune therapies for autoimmune diseases, cytokine therapies have emerged as a specialized strategy, targeting cytokine-mediated regulatory pathways to rectify immunological imbalances. Proinflammatory cytokines are key players in inducing and propagating autoimmune inflammation, highlighting the potential of cytokine therapies in managing autoimmune conditions. This review discusses the etiology of autoimmune diseases, current therapeutic approaches, and prospects for future drug design. Full article
(This article belongs to the Special Issue Mechanisms of Immune Tolerance and Autoimmune Diseases)
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