Molecular Mechanism of Leukemogenesis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 909
Special Issue Editor
Interests: acute myeloid leukemia; leukemogenesis; epigenetics; transcription factor; oncoprotein; signal transduction; cell cycle; novel strategies; targeted therapy; apoptosis; apoptosis rate; article; biogenesis; bioinformatics; cell count; cell proliferation; controlled study; flow cytometry; genetic transfection; human; human cell; human tissue; liquid chromatography-mass spectrometry; major clinical study; mass spectrometry; northern blotting; protein expression; protein function; protein synthesis; proteomics; real time polymerase chain reaction; real time reverse transcription polymerase chain reaction; RNA sequencing; RNA translation; transcriptome sequencing; western blotting; B cell acute lymphoblastic leukemia; carcinogenesis; child; chromosome analysis; copy number variation; cytogenetics; DNA extraction; female; follow up; gene fusion; gene mutation; gene rearrangement; high throughput sequencing; immunophenotyping; infant; leukocyte count; male; microarray analysis; minimal residual
Special Issue Information
Dear Colleagues,
Leukemias have been the spearhead of our understanding of how cancer develops. Leukemias are one of the diseases for which great leaps have been made in the development of specific treatments; through this precision medicine, we have transitioned from 0% survival in the last 80 years to almost 90% survival in some childhood leukemias. In the case of leukemias, many of the molecular mechanisms related to their development are mechanisms related to treatment and mechanisms that will allow us to understand the development of other cancers. The molecular mechanisms related to the origin of these neoplasms allow us to understand the degree to which they progress from pre-leukemic states such as myelodysplastic syndromes to the final development of leukemias. But these mechanisms are also present in children with Down's syndrome, which has allowed us to understand the progression from a transient dysmelopoiesis syndrome of the newborn to the development of leukemia. The approach of molecular mechanisms in leukemiogenesis will allow us to better understand this pathology in order to design targeted prevention strategies and advances in precision medicine for this pathology to further increase the survival of patients suffering from these pathologies.
Dr. Juan Manuel Mejia-Arangure
Guest Editor
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Keywords
- leukemias
- molecular mechanisms
- leukemiogenesis
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