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Chronic Obstructive Pulmonary Diseases
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Chronic Obstructive Pulmonary Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 10643

Special Issue Editor

Prof. Dr. Patrizia Russo

E-Mail Website
Guest Editor
1. Department of Human Sciences and Promotion of the Quality of Life, San Raffaele University, Via di Val Cannuta 247, 00166 Rome, Italy
2. Clinical and Molecular Epidemiology, IRCCS San Raffaele Roma, Via di Val Cannuta 247, 00166 Rome, Italy
Interests: DNA damage; nicotine and nicotinic receptor; COVID-19; respiratory disease; toeque teno virus
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

COPD causes chronic airflow limitation, breathlessness, exercise intolerance, cough, difficulty with daily activities, infections, acute exacerbations (AECOPD) and (re)hospitalization. COPD is a multisystem disease with effects beyond the lung that are associated with prognosis and mortality. COPD is characterized by a complex GxG/GxE interactions not yet completely understood. Many genes are associated with COPD genesis and development and therapy. Genetic variants (SNPs) are associated with COPD susceptibility, severity airway hyperactivity, FEV, and therapeutic response. Cellular senescence is implicated in COPD pathogenesis; thus lung senescent cells release senescence-associated secretory phenotype (SASP) factors. Viral and bacterial infections of the respiratory system are a major cause of COPD exacerbations, leading increased local and systemic inflammation.
In this Special Issue, studies using animal or cell culture models to investigate molecular mechanisms of COPD will be published. This Special Issue will also cover reports on patients, providing novel mechanistic insights into the underlying pathogenesis or new aspects that may impact therapy.

Dr. Patrizia Russo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • COPD
  • multisystem disease
  • biomarker
  • genomic
  • outcome

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Published Papers (2 papers)

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Review

12 pages, 1222 KiB  
Review
Nerve Growth Factor: A Potential Therapeutic Target for Lung Diseases
by Piaoyang Liu, Shun Li and Liling Tang
Int. J. Mol. Sci. 2021, 22(17), 9112; https://doi.org/10.3390/ijms22179112 - 24 Aug 2021
Cited by 23 | Viewed by 4402
Abstract
The lungs play a very important role in the human respiratory system. However, many factors can destroy the structure of the lung, causing several lung diseases and, often, serious damage to people’s health. Nerve growth factor (NGF) is a polypeptide which is widely [...] Read more.
The lungs play a very important role in the human respiratory system. However, many factors can destroy the structure of the lung, causing several lung diseases and, often, serious damage to people’s health. Nerve growth factor (NGF) is a polypeptide which is widely expressed in lung tissues. Under different microenvironments, NGF participates in the occurrence and development of lung diseases by changing protein expression levels and mediating cell function. In this review, we summarize the functions of NGF as well as some potential underlying mechanisms in pulmonary fibrosis (PF), coronavirus disease 2019 (COVID-19), pulmonary hypertension (PH), asthma, chronic obstructive pulmonary disease (COPD), and lung cancer. Furthermore, we highlight that anti-NGF may be used in future therapeutic strategies. Full article
(This article belongs to the Special Issue Chronic Obstructive Pulmonary Diseases)
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28 pages, 1609 KiB  
Review
The Role of ABC Transporters in Lipid Metabolism and the Comorbid Course of Chronic Obstructive Pulmonary Disease and Atherosclerosis
by Stanislav Kotlyarov and Anna Kotlyarova
Int. J. Mol. Sci. 2021, 22(13), 6711; https://doi.org/10.3390/ijms22136711 - 23 Jun 2021
Cited by 20 | Viewed by 5514
Abstract
Chronic obstructive pulmonary disease (COPD) ranks among the leading causes of morbidity and mortality worldwide. COPD rarely occurs in isolation and is often combined with various diseases. It is considered that systemic inflammation underlies the comorbid course of COPD. The data obtained in [...] Read more.
Chronic obstructive pulmonary disease (COPD) ranks among the leading causes of morbidity and mortality worldwide. COPD rarely occurs in isolation and is often combined with various diseases. It is considered that systemic inflammation underlies the comorbid course of COPD. The data obtained in recent years have shown the importance of violations of the cross-links of lipid metabolism and the immune response, which are links in the pathogenesis of both COPD and atherosclerosis. The role of lipid metabolism disorders in the pathogenesis of the comorbid course of COPD and atherosclerosis and the participation of ATP-binding cassette (ABC) transporters in these processes is discussed in this article. It is known that about 20 representatives of a large family of ABC transporters provide lipid homeostasis of cells by moving lipids inside the cell and in its plasma membrane, as well as removing lipids from the cell. It was shown that some representatives of the ABC-transporter family are involved in various links of the pathogenesis of COPD and atherosclerosis, which can determine their comorbid course. Full article
(This article belongs to the Special Issue Chronic Obstructive Pulmonary Diseases)
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