Advanced Therapy Using Human Mesenchymal Stem Cells (MSCs) and MSC Extracellular Vesicles
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 February 2025 | Viewed by 957
Special Issue Editors
Interests: MSC and iPSC medium development; critical quality attributes (CQAs) of MSC manufacturing; mesenchymal stem cell stemness and ageing; gene therapy and cell therapy of human mesenchymal stem cells (hMSCs) for bone and cartilage regeneration; bone and cartilage disease modeling; drug screening and gene correction via iPSCs; immortalization of hMSCs
Interests: bioceramics; material-induced osteoinduction; biomaterials for orthopaedics; bioengineering; bone and cartilage regeneration; mesenchymal stem cell for bone and cartilage regeneration; bone and cartilage disease modeling; biological evaluation of implantable devices; animal models
Special Issue Information
Dear Colleagues,
Human mesenchymal stem cells (MSCs) are one of the most used stem cells for clinical applications. So far, MSCs have been used in over 1500 clinical trials to treat over 30 diseases. However, MSC applications are being greatly affected by several limitations, such as limited lifespan, gradual loss of MSC stemness during in vitro expansion, cell rejection during transplant etc. Extracellular vesicles (EVs), particularly exosomes, are small membrane-bound particles secreted by cells. EVs carry various bioactive molecules such as proteins, lipids, mRNAs, and miRNAs, which contribute to their therapeutic effects. MSC-derived EVs are considered to mediate many of the therapeutic effects previously attributed to MSCs themselves, offering a cell-free alternative in regenerative medicine. Due to the advantages of MSC-EVs in cell-free approaches, i.e., their scalability and safety, MSC-EVs have been used for anti-inflammatory effects, tissue repair, neurological disorders, and cancer therapy.
Advanced therapy using MSCs and MSC-EVs is an emerging field for enhanced regenerative medicine and cell-based/free therapy. These approaches leverage the biological properties of MSCs and their secreted EVs to treat various conditions, including tissue injuries, inflammation, and degenerative diseases.
This Special Issue of the International Journal of Molecular Sciences titled “Advanced Therapy Using Human Mesenchymal Stem Cells (MSCs) and MSC Extracellular Vesicles” will include a selection of scientific contributions aimed at presenting the development and applications using MSCs and MSC-EVs, including cell therapy, gene therapy, EV characterization/standardization and application, manufacturing and scale-up, and mechanistic understanding to address personalized and regenerative medicine approaches.
Original research, review articles, preclinical studies, short communications, and letters on all topics in these research fields are invited.
This Special Issue is now open for submissions. If you are interested in contributing your work, please send a tentative title or short abstract to the Guest Editor or Editorial Office.
Dr. Tong Ming Liu
Dr. Xiaoman Luo
Guest Editors
Manuscript Submission Information
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Keywords
- mesenchymal stem cells
- extracellular vesicles
- MSCs
- MSC-EVs
- regenerative medicine
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