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Carbohydrate, Lipid and Protein Metabolism in Human Health and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 4363

Special Issue Editors

School of Chemical Engineering and Technology, Hainan University, Haikou, China
Interests: food nutrition; food processing and storage; metabolic syndrome; metabonomics; lipidomics; lipid metabolism; diet-induced obesity; protein; inflammation
Special Issues, Collections and Topics in MDPI journals
Spice and Beverage Research Institute, Chinese Academy of Tropical Agricultural Sciences, Wanning 571533, China
Interests: carbohydrate polymers; metabonomics; lipidomics; prebiotics; gut microbiota; glucose metabolism; fatty acid metabolism; lipid metabolism; obesity; diabetes mellitus; inflammation bowel disease; immune regulation; antioxidant activity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Carbohydrate, lipid and protein metabolism is an essential and complex biochemical reaction in the organism. With the help of enzymes, the three kinds of macronutrients involved varieties of digestion and absorption, synthesis and decomposition. The process of material processed into the body's needs guarantees the regular operation of the physiological function and is of great significance for health. Abnormal carbohydrate, lipid and protein metabolism profiles and changes can profoundly affect cell function, the immune system, antioxidant defenses, and inflammatory responses. The advent of new tools and information technologies have made it feasible to analyze entire glycomics, lipidomics, proteomics and metabolomics in biofluids and tissues. The determination of individual macronutrient characteristics (composition and abundance) in biosamples could be a powerful tool that can be used to understand the mechanisms of carbohydrate, lipid and protein-based diseases. The mechanisms that link carbohydrate, lipid and protein metabolism and metabolic syndrome have been studied, but remain not fully understood. We kindly invite investigators to contribute both original research and review articles that are in accordance with this Special Issue, which focuses on the role and mechanisms of carbohydrate, lipid and protein metabolism associate with related diseases, including obesity, diabetes, non-alcoholic fatty liver disease (NAFLD/NASH), atherosclerosis, hypertension, and coronary artery diseases. Subtopics that are also of interest include, but are not limited to, the followings:

  • The importance and application of carbohydrate, lipid and protein lipids in health and disease;
  • Carbohydrate, lipid and protein as diagnostic and prognostic biomarkers of disease;
  • Carbohydrate, lipid and protein in systems biology and metabolic networks;
  • New advances in carbohydrate, lipid and protein analysis and metabolomics.

Dr. Chuan Li
Dr. Kexue Zhu
Guest Editors

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Keywords

  • glycometabolism
  • lipid metabolism
  • amino acid metabolism
  • energy metabolism
  • metabonomics
  • diabetes mellitus
  • obesity
  • metabolic syndrome
  • dyslipidemia
  • inflammation
  • insulin resistance
  • nonalcoholic fatty liver

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Published Papers (1 paper)

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Research

14 pages, 3816 KiB  
Article
Polysaccharides from Holothuria leucospilota Relieve Loperamide-Induced Constipation Symptoms in Mice
by Ziqi Wang, Yali Shi, Shiyu Zeng, Yuanping Zheng, Huaijie Wang, Haihui Liao, Jie Song, Xinyue Zhang, Jun Cao and Chuan Li
Int. J. Mol. Sci. 2023, 24(3), 2553; https://doi.org/10.3390/ijms24032553 - 29 Jan 2023
Cited by 9 | Viewed by 2913
Abstract
A vital bioactive component of marine resources is Holothuria leucospilota polysaccharides (HLP). This study examined whether HLP could regulate intestinal flora to treat loperamide-induced constipation. Constipated mice showed signs of prolonged defecation (up by 60.79 min) and a reduced number of bowel movements [...] Read more.
A vital bioactive component of marine resources is Holothuria leucospilota polysaccharides (HLP). This study examined whether HLP could regulate intestinal flora to treat loperamide-induced constipation. Constipated mice showed signs of prolonged defecation (up by 60.79 min) and a reduced number of bowel movements and pellet water content (decreased by 12.375 and 11.77%, respectively). The results showed that HLP treatment reduced these symptoms, reversed the changes in related protein expression levels in the colon, and regulated the levels of active peptides associated with the gastrointestinal tract in constipated mice, which significantly improved water-electrolyte metabolism and enhanced gastrointestinal motility. Meanwhile, it was found that intestinal barrier damage was reduced and the inflammatory response was inhibited through histopathology and immunohistochemistry. As a means to further relieve constipation symptoms, treatment with low, medium, and high HLP concentrations increased the total short-chain fatty acid (SCFA) content in the intestine of constipated mice by 62.60 μg/g, 138.91 μg/g, and 126.51 μg/g, respectively. Moreover, an analysis of the intestinal flora’s gene for 16S rRNA suggested that the intestinal microbiota was improved through HLP treatment, which is relevant to the motivation for the production of SCFAs. In summary, it was demonstrated that HLP reduced loperamide-induced constipation in mice. Full article
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