Connexin and Pannexin Signaling in Health and Disease 3.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 2975
Special Issue Editor
Interests: in vitro toxicology; experimental hepatology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Gap junctions play a critical role in a plethora of physiological processes by facilitating direct intercellular communication. They are composed of two hemichannels of neighbouring cells, which in turn are built up by six connexin proteins. Over the past two decades, it has become clear that connexin hemichannels can also provide a pathway for cellular communication on their own, albeit between the cytosol of an individual cell and its extracellular environment. Furthermore, a novel class of connexin-like proteins was identified 20 years ago, namely, pannexins, which gather at the cell plasma membrane surface in a configuration reminiscent of connexin hemichannels. Unlike gap junctions, connexin hemichannels and pannexin channels seem to become active predominantly under pathological conditions by supporting inflammation and cell death.
This Special Issue of the International Journal of Molecular Sciences focuses on the connexin and pannexin research field, and welcomes both original research articles and review papers that deal with the molecular mechanisms underlying the role of connexin and pannexin signaling in health and disease.
Prof. Dr. Mathieu Vinken
Guest Editor
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Keywords
- connexin
- pannexin
- hemichannel
- gap junction
- physiology
- pathology
- mechanisms
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