Periodontitis: Advances in Mechanisms, Treatment and Prevention
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 March 2025 | Viewed by 4725
Special Issue Editor
Special Issue Information
Dear Colleagues,
Periodontitis, a chronic inflammatory disease affecting the supporting structures of the teeth, poses a significant public health concern globally. Despite advancements in understanding its etiology and treatment modalities, periodontitis continues to exert a considerable burden on oral health and overall well-being. Molecular mechanisms underlying the onset, progression, and resolution of periodontitis remain areas of intense research, holding promise for novel therapeutic interventions and preventive strategies. This Special Issue aims to provide a comprehensive overview of recent advances in the molecular understanding of periodontitis, with a focus on mechanisms, correlations with systemic diseases, treatment innovations, and preventive measures. Submissions may include original research articles, review papers, meta-analyses, case studies, and perspectives covering but not limited to the following:
- Genetic and Epigenetic Factors in Periodontitis: The exploration of genetic predispositions and epigenetic modifications contributing to periodontal susceptibility, progression, and response to treatment.
- Host–Pathogen Interactions: Investigating the molecular crosstalk between host immune responses and periodontal pathogens, including biofilm formation, immune evasion strategies, and microbial dysbiosis.
- Inflammatory Signaling Pathways: Elucidating the molecular pathways involved in periodontal inflammation, including cytokine networks, Toll-like receptor signaling, and inflammasome activation.
- Tissue Destruction Mechanisms: Understanding the molecular mechanisms underlying alveolar bone resorption, periodontal ligament degradation, and gingival tissue breakdown in periodontitis.
- Emerging Therapeutic Targets: Reviewing novel molecular targets for periodontal therapy, such as anti-inflammatory agents, host modulation therapy, and antimicrobial peptides.
- Precision Dentistry Approaches: Examining personalized treatment strategies based on molecular profiling, including biomarker identification, targeted drug delivery, and regenerative therapies.
- Role of Microbiome in Periodontal Health: Investigating the interplay between the oral microbiome composition, microbial diversity, and periodontal disease progression at the molecular level.
- Advancements in Periodontal Diagnostics: Discussing molecular diagnostic tools, including saliva biomarkers, microbial DNA/RNA sequencing, and point-of-care testing for the early detection and monitoring of periodontitis.
- Nutritional and Lifestyle Interventions: Exploring the impact of diet, smoking, and other lifestyle factors on periodontal health from a molecular perspective, and their implications for preventive strategies.
- Future Directions and Translational Research: Identifying gaps in knowledge and proposing future research directions to translate molecular findings into clinical practice, fostering interdisciplinary collaborations.
This Special Issue aims to consolidate the latest advancements in molecular research on periodontitis, providing a platform for interdisciplinary dialogue and knowledge exchange. By fostering collaboration among researchers and clinicians, we aspire to accelerate the translation of molecular insights into innovative strategies for periodontal disease management and prevention.
Dr. Alessandro Polizzi
Guest Editor
Manuscript Submission Information
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Keywords
- periodontitis
- genetic
- epigenetic
- signaling pathways
- therapeutic target
- precision dentistry
- non-surgical periodontal treatment
- systemic diseases
- oral microbiome
- risk factors
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