MS-Based Protein Specific Analysis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Macromolecules".
Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 31882
Special Issue Editor
Interests: mass spectrometry; hyphenation; separation techniques; native protein analysis; affinity separations; automatization; protein characterization; biopharmaceuticals; clinical analysis
Special Issue Information
Dear Colleagues,
Proteins are essential macromolecules required in the structure, function, and regulation of many processes in living organisms. Proteins are very diverse and often comprise genetic variants and posttranslational modifications (i.e., proteoforms). Assessing protein and proteoform variability is essential – yet challenging – in many research areas, including medical, biological, and chemical sciences. Mass spectrometry (MS) has become the primary tool for the structural characterization of proteins and many different MS-based approaches – from bottom-up to intact and top-down approaches – are currently being used for protein identification and proteoform characterization. Often, upfront separation of proteins is necessary to unravel the vast heterogeneity and obtain accurate mass information. Thanks to recent technological developments in MS instrumentation, separation technology, and coupling options, online approaches are gaining a predominant position in the MS toolbox for protein analysis.
This Special Issue will focus on MS-based protein analysis and will cover recent methodological developments and relevant applications. Applications may cover characterization of novel endogenous or recombinant proteins, biomarker discovery, or biologically relevant proteomic studies, among others. Original research work, communications as well as reviews in the field are welcome to this Special Issue.
Dr. Elena Domínguez-Vega
Guest Editor
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Keywords
- Mass spectrometry
- Top-down proteomics
- Bottom-up proteomics
- Intact protein analysis
- Middle-up/down characterization
- Hyphenation
- Post-translational modifications
- Proteoforms
- Endogenous proteins
- Biopharmaceuticals
- Industrial enzymes
- Clinical proteomics
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