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Research and Application of Platelet-Rich Plasma (PRP)
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Research and Application of Platelet-Rich Plasma (PRP)

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 February 2025 | Viewed by 3596

Special Issue Editor

Dr. Tomoyuki Kawase

E-Mail Website
Guest Editor
Division of Oral Bioengineering, Institute of Medicine and Dentistry, Niigata University, Niigata 951-8514, Japan
Interests: platelet concentrates; regenerative dentistry; tissue engineering; quality control
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Since it was first reported in the 1990s, platelet concentrations, such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), have been applied in tissue regenerative therapy in various fields. The theoretical basis for use is that concentrated growth factors can be provided by platelet concentrates without serious adverse effects. The advantages of this therapy are its high cost-effectiveness ratio, non-limited commercial availability, and lack of risk of pathogen transfection.

In this Special Issue, we aim to highlight the role of platelets. If non-responders can be detected by monitoring platelet physiological functions and biochemical reactions at molecular levels, this would help realize more predictable PRP therapy. However, the topics of interest are not limited to the aforementioned topics. All in all, in this Special Issue, we explore cutting-edge research on platelet-rich plasma (PRP) and its applications in various biomedical fields. Original, impactful, cutting-edge research and insightful review articles regarding the basic aspects of PRP therapy are highly desirable.

Dr. Tomoyuki Kawase
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • platelet-rich plasma
  • platelet-rich fibrin
  • platelets
  • exosome
  • mitochondria
  • growth factors
  • tissue regeneration

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Published Papers (3 papers)

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Research

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18 pages, 3160 KiB  
Article
Investigating the Biological Efficacy of Albumin-Enriched Platelet-Rich Fibrin (Alb-PRF): A Study on Cytokine Dynamics and Osteoblast Behavior
by Emanuelle Stellet Lourenço, Neilane Rodrigues Santiago Rocha, Renata de Lima Barbosa, Rafael Coutinho Mello-Machado, Victor Hugo de Souza Lima, Paulo Emilio Correa Leite, Mariana Rodrigues Pereira, Priscila Ladeira Casado, Tomoyuki Kawase, Carlos Fernando Mourão and Gutemberg Gomes Alves
Int. J. Mol. Sci. 2024, 25(21), 11531; https://doi.org/10.3390/ijms252111531 - 27 Oct 2024
Viewed by 758
Abstract
The development of effective biomaterials for tissue regeneration has led to the exploration of blood derivatives such as leucocyte- and platelet-rich fibrin (L-PRF). A novel variant, Albumin-Enriched Platelet-Rich Fibrin (Alb-PRF), has been introduced to improve structural stability and bioactivity, making it a promising [...] Read more.
The development of effective biomaterials for tissue regeneration has led to the exploration of blood derivatives such as leucocyte- and platelet-rich fibrin (L-PRF). A novel variant, Albumin-Enriched Platelet-Rich Fibrin (Alb-PRF), has been introduced to improve structural stability and bioactivity, making it a promising candidate for bone regeneration. This study aimed to evaluate Alb-PRF’s capacity for cytokine and growth factor release, along with its effects on the proliferation, differentiation, and mineralization of human osteoblasts in vitro. Alb-PRF membranes were analyzed using histological, scanning electron microscopy, and fluorescence microscopy techniques. Cytokine and growth factor release was quantified over seven days, and osteoinductive potential was evaluated with MG-63 osteoblast-like cells. Structural analysis showed Alb-PRF as a biphasic, highly cellularized material that releases lower levels of inflammatory cytokines and higher concentrations of platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) compared to L-PRF. Alb-PRF exhibited higher early alkaline phosphatase activity and in vitro mineralization (p < 0.05) and significantly increased the OPG/RANKL mRNA ratio (p < 0.05). These results indicate that Alb-PRF has promising potential as a scaffold for bone repair, warranting further in vivo and clinical assessments to confirm its suitability for clinical applications. Full article
(This article belongs to the Special Issue Research and Application of Platelet-Rich Plasma (PRP))
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16 pages, 11849 KiB  
Article
Platelet-Rich Plasma (PRP) Based on Simple and Efficient Integrated Preparation Precises Quantitatively for Skin Wound Repair
by Mengjie Qiu, Yating He, Haijie Zhang, Yunquan Zheng, Xianai Shi and Jianmin Yang
Int. J. Mol. Sci. 2024, 25(17), 9340; https://doi.org/10.3390/ijms25179340 - 28 Aug 2024
Viewed by 886
Abstract
Platelet-rich plasma (PRP) has become an important regenerative therapy. However, the preparation method of PRP has not been standardized, and the optimal platelet concentration for PRP used in skin wound repair is unclear, leading to inconsistent clinical efficacy of PRP. Therefore, the development [...] Read more.
Platelet-rich plasma (PRP) has become an important regenerative therapy. However, the preparation method of PRP has not been standardized, and the optimal platelet concentration for PRP used in skin wound repair is unclear, leading to inconsistent clinical efficacy of PRP. Therefore, the development of standardized preparation methods for PRP and the investigation of the dose-response relationship between PRP with different platelet concentrations and tissue regeneration plays an important role in the development and clinical application of PRP technology. This study has developed an integrated blood collection device from blood drawing to centrifugation. Response surface methodology was employed to optimize the preparation conditions, ultimately achieving a platelet recovery rate as high as 95.74% for PRP (with optimal parameters: centrifugation force 1730× g, centrifugation time 10 min, and serum separation gel dosage 1.4 g). Both in vitro and in vivo experimental results indicate that PRP with a (2×) enrichment ratio is the most effective in promoting fibroblast proliferation and skin wound healing, with a cell proliferation rate of over 150% and a wound healing rate of 78% on day 7. Full article
(This article belongs to the Special Issue Research and Application of Platelet-Rich Plasma (PRP))
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Review

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21 pages, 1521 KiB  
Review
The Biological Role of Platelet Derivatives in Regenerative Aesthetics
by Lorena Cristina Santos, Giselle Lobo Lana, Gabriel Silva Santos, Silvia Beatriz Coutinho Visoni, Rayssa Junqueira Brigagão, Napoliane Santos, Rafaela Sobreiro, Andreza da Cruz Silva Reis, Bruno Lima Rodrigues, Sabrina Ferrari, Claudia Herrera Tambeli and José Fábio Lana
Int. J. Mol. Sci. 2024, 25(11), 5604; https://doi.org/10.3390/ijms25115604 - 21 May 2024
Cited by 4 | Viewed by 1337
Abstract
Bioproducts derived from platelets have been extensively used across various medical fields, with a recent notable surge in their application in dermatology and aesthetic procedures. These products, such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), play crucial roles in inducing blood vessel [...] Read more.
Bioproducts derived from platelets have been extensively used across various medical fields, with a recent notable surge in their application in dermatology and aesthetic procedures. These products, such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), play crucial roles in inducing blood vessel proliferation through growth factors derived from peripheral blood. PRP and PRF, in particular, facilitate fibrin polymerization, creating a robust structure that serves as a reservoir for numerous growth factors. These factors contribute to tissue regeneration by promoting cell proliferation, differentiation, and migration and collagen/elastin production. Aesthetic medicine harnesses these effects for diverse purposes, including hair restoration, scar treatment, striae management, and wound healing. Furthermore, these biological products can act as adjuvants with other treatment modalities, such as laser therapy, radiofrequency, and microneedling. This review synthesizes the existing evidence, offering insights into the applications and benefits of biological products in aesthetic medicine. Full article
(This article belongs to the Special Issue Research and Application of Platelet-Rich Plasma (PRP))
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