Editorial Board Members’ Collection Series: “Advanced NK Cell-Based Approaches for Cancer Immunotherapy”
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (31 August 2024) | Viewed by 233
Special Issue Editors
Interests: cancer immunotherapy; natural compounds and cancer; cancer vaccines; cancer prevention and treatment in preclinical models
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Natural Killer (NK) cells play an essential role in killing cancer cells. Cancer patients generally harbor dysfunctional and a reduced number of effector immune cells, including NK cells. Thus, the adoptive transfer of autologous or allogeneic ex vivo-activated NK or genetically modified NK cells is a promising cellular therapy. In this Special Issue, we welcome the submission of Original Research, Review, and Opinion articles that enhance our understanding of the recent advances in molecular strategies aimed to boost the NK cell-mediated killing of tumor cells and that provide insights into new viewpoints on the adoption of NK cells in cancer immunotherapy. This article collection aims to cover the following aspects:
- Molecular strategies aimed at enhancing the expression of surface-activating ligands on tumor cells.
- Targeting molecular pathways that facilitate the NK cell-mediated ADCC.
- Molecular strategies promoting the production of chemoattractant molecules in the tumor microenvironment.
- Molecular strategies enhancing the expression of ligands for integrins and molecules involved in the formation of an activating synapse between tumor and NK cells.
- Strategies that target immune checkpoint inhibitors, combined with adoptively transferred NK cells.
- The generation of chimeric receptor-engineered NK cells to be adopted for the clinical treatment of cancer patients.
Prof. Dr. Roberto Bei
Dr. Loredana Cifaldi
Guest Editors
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Keywords
- NK
- CAR-NK
- cancer
- immunotherapy
- solid tumor
- hematopoietic tumor
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