ijms-logo

Journal Browser

Journal Browser

Ferroptosis: Emerging Mechanisms, Physiological Functions, and Therapeutic Applications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 20 January 2025 | Viewed by 1344

Special Issue Editor


E-Mail Website
Guest Editor
Department of Genetics, Cell Biology and Anatomy, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA
Interests: bioinformatics; machine learning; computational biology; genomics; cancer research; single cell analysis; multi-omics analysis; spatial transcriptomics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Ferroptosis is a form of programmed cell death that is triggered by the accumulation of intracellular lipid peroxidation and is dependent on iron. Recent studies have shown that ferroptosis plays a crucial role in regulating cell oxidative stress, metabolism, and immune response, and is involved in various physiological and pathological processes in the body. It is now understood that ferroptosis can inhibit tumor growth and enhance the effectiveness of chemotherapy and immunotherapy in treating cancer. However, ferroptosis can also lead to damage in normal tissues and organs, contributing to the development of diseases such as cardiovascular and neurodegenerative disorders. By targeting ferroptosis and understanding its role in disease progression, researchers can develop new strategies for treatment and potentially improve human health outcomes.

In this Special Issue, we invite submissions of perspective, original article, review, commentary, or letter type of manuscripts that delve into topics such as, but not limited to, the following:

  1. ferroptosis and disease occurrence and/or development;
  2. ferroptosis biomarkers for lipid and/or iron metabolism in the onset and progression of diseases;
  3. Gene regulation of ferroptosis in diseases;
  4. Development and application of ferroptosis inhibitors and agonists (including nanomaterials);
  5. Application of ferroptosis in precision medicine and clinical transformation.

Dr. Shibiao Wan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ferroptosis
  • biomarker
  • iron metabolism
  • diseases
  • precision medicine

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

26 pages, 6695 KiB  
Article
A Systems Biology Approach Towards a Comprehensive Understanding of Ferroptosis
by Mikhail Arbatskiy, Dmitriy Balandin, Ilya Akberdin and Alexey Churov
Int. J. Mol. Sci. 2024, 25(21), 11782; https://doi.org/10.3390/ijms252111782 - 2 Nov 2024
Viewed by 1006
Abstract
Ferroptosis is a regulated cell death process characterized by iron ion catalysis and reactive oxygen species, leading to lipid peroxidation. This mechanism plays a crucial role in age-related diseases, including cancer and cardiovascular and neurological disorders. To better mimic iron-induced cell death, predict [...] Read more.
Ferroptosis is a regulated cell death process characterized by iron ion catalysis and reactive oxygen species, leading to lipid peroxidation. This mechanism plays a crucial role in age-related diseases, including cancer and cardiovascular and neurological disorders. To better mimic iron-induced cell death, predict the effects of various elements, and identify drugs capable of regulating ferroptosis, it is essential to develop precise models of this process. Such drugs can be tested on cellular models. Systems biology offers a powerful approach to studying biological processes through modeling, which involves accumulating and analyzing comprehensive research data. Once a model is created, it allows for examining the system’s response to various stimuli. Our goal is to develop a modular framework for ferroptosis, enabling the prediction and screening of compounds with geroprotective and antiferroptotic effects. For modeling and analysis, we utilized BioUML (Biological Universal Modeling Language), which supports key standards in systems biology, modular and visual modeling, rapid simulation, parameter estimation, and a variety of numerical methods. This combination fulfills the requirements for modeling complex biological systems. The integrated modular model was validated on diverse datasets, including original experimental data. This framework encompasses essential molecular genetic processes such as the Fenton reaction, iron metabolism, lipid synthesis, and the antioxidant system. We identified structural relationships between molecular agents within each module and compared them to our proposed system for regulating the initiation and progression of ferroptosis. Our research highlights that no current models comprehensively cover all regulatory mechanisms of ferroptosis. By integrating data on ferroptosis modules into an integrated modular model, we can enhance our understanding of its mechanisms and assist in the discovery of new treatment targets for age-related diseases. A computational model of ferroptosis was developed based on a modular modeling approach and included 73 differential equations and 93 species. Full article
Show Figures

Figure 1

Back to TopTop