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Bioactive Compounds from Natural Products for the Prevention and Treatment of Chronic Diseases, 3rd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 March 2025 | Viewed by 1556

Special Issue Editor

Special Issue Information

Dear Colleagues,

Natural products may be the oldest form of medicine in human history. In particular, the types of medicine and functional foods using natural compounds are increasing. The aging of society due to the extension of life expectancy is one of the reasons treatments using natural compounds are receiving attention. As the elderly population increases, the number of patients with chronic and degenerative diseases does as well. These diseases have a high risk of side effects due to the nature of taking medicine for extended periods. Therefore, the relatively high safety and low side effects of natural products are very advantageous in the treatment of chronic diseases in this aging society. For these reasons, this Special Issue aims to identify bioactive compounds from natural products for the prevention and treatment of chronic diseases through signaling pathways in vitro or in vivo. We invite you to contribute your current work to this Special Issue as original research articles, review articles, and short communications.

Dr. Dong-Sung Lee
Guest Editor

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Keywords

  • natural products
  • natural products isolation
  • bioactive natural compounds
  • inflammation
  • neurodegenerative diseases
  • skin diseases
  • cancer
  • metabolic syndrome
  • chronic diseases

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Published Papers (1 paper)

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Research

13 pages, 10432 KiB  
Article
Immunostimulatory Activity of a Mixture of Platycodon grandiflorum, Pyrus serotine, Chaenomeles sinensis, and Raphanus sativus in RAW264.7 Macrophages
by Weerawan Rod-in, Minji Kim, A-yeong Jang, Yu Suk Nam, Tae Young Yoo and Woo Jung Park
Int. J. Mol. Sci. 2024, 25(19), 10660; https://doi.org/10.3390/ijms251910660 - 3 Oct 2024
Viewed by 1063
Abstract
In this study, a mixture of Platycodon grandiflorum, Pyrus serotina, Chaenomeles sinensis, and Raphanus sativus (PPCRE) was investigated for their immuno-enhancing effects, as well as the molecular mechanism of PPCRE in RAW264.7 cells. PPCRE dramatically increased nitric oxide (NO) and [...] Read more.
In this study, a mixture of Platycodon grandiflorum, Pyrus serotina, Chaenomeles sinensis, and Raphanus sativus (PPCRE) was investigated for their immuno-enhancing effects, as well as the molecular mechanism of PPCRE in RAW264.7 cells. PPCRE dramatically increased nitric oxide (NO) and prostaglandin E2 (PGE2) generation depending on the concentration while exhibiting no cytotoxicity. PPCRE markedly upregulated the mRNA and protein expression of immune-related cytotoxic factors such as cyclooxygenase (COX)-1, COX-2, and inducible nitric oxide synthase (iNOS) and pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6, and tumor necrosis factor alpha (TNF-α), as well as the mRNA level of IL-4. PPCRE increased the mitogen-activated protein kinase (MAPK) signaling pathway by upregulating the phosphorylation of extracellular signal-regulated kinase (ERK), stress-activated protein kinase/Jun N-terminal-kinase (SAPK/JNK), and p38. Furthermore, PPCRE considerably activated the nuclear factor kappa B (NF-κB) signaling pathway by increasing phosphorylation of NF-κB-p65. PPCRE-stimulated RAW264.7 cells increased macrophage phagocytic capacity. In conclusion, our study found that PPCRE improved immune function by modulating inflammatory mediators and regulating the MAPK and NF-κB pathway of signaling in macrophages. Full article
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