ijms-logo

Journal Browser

Journal Browser

Selected Papers for the 30th International Conference on Chelation (ICOC)—a Landmark on Metal Chelation Science and Medicine

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 2119

Special Issue Editor


E-Mail Website
Guest Editor
Postgraduate Research Institute of Science, Technology, Environment and Medicine, CY-3021 Limassol, Cyprus
Interests: chelation therapy; chelation in medicine; chelating drugs; iron chelating drugs in thalassaemia and other diseases of iron overload or imbalance; chelator antioxidants in free radical pathology; chelators and antioxidants in cancer and neurodegenerative diseases; chelating drug design, development and clinical use
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We present this Special Issue as part of an announcement of the forthcoming 30th International Conference on Chelation (ICOC), which will take place in Paphos, Cyprus, in 2024. Since the first ICOC in 1989, which took place in London, UK, hundreds of papers from the ICOC proceedings have been published in various international journals, expounding critical subject matters such as the introduction of oral iron chelation therapy, the complete treatment of iron overload, the treatment of cancer, neurodegenerative and other diseases, new iron and other metal complexes for the treatment of iron deficiency, and theranostic and diagnostic applications, among others. This will be the first ICOC proceedings accepting relevant research articles, which will be published in the open access platform journal IJMS. The 30th ICOC will take place in conjunction with the 12th Recent Advances in Health and Medical Sciences (RAHMS) and the 9th Oncology and Anticancer Research (ICOAR), in a multidisciplinary forum. This invitation applies to all interested colleagues and participants or non-participants of the 30th ICOC with regard to any of the following (or other unlisted but relevant) topics:

  1. Oncology and anticancer research, e.g., ferroptosis, iron metabolisms, and metal ions in cancer.
  2. Trace elements, diagnostic and theranostic metals in health and disease.
  3. Free radicals and antioxidants in health and disease.
  4. Thalassemia and other hemoglobinopathies; iron deficiency anemia; anemia of inflammation.
  5. Chelation therapy, e.g., deferiprone, deferoxamine, deferasirox, EDTA, DTPA, natural chelators.
  6. Iron toxicity in neurodegenerative, heart, kidney, liver diseases, and associated treatments.
  7. Recent advances on iron metabolism and proteins; related diseases and biological therapies.
  8. Microbial diseases and treatments.
  9. Nutrition and food sciences in health and disease.
  10. Drug design, development, and clinical use.
  11. Drug toxicology and metal toxicology.
  12. Traditional Chinese, alternative, and homeopathic medicine.

We cordially invite you to submit your research to the Special Issue entitled Selected Papers of the 30th International Conference on Chelation (ICOC)—A Landmark on Metal Chelation Science and Medicine, in association with the organization of the 30th ICOC in 2024. In line with the policy of IJMS, this Special Issue focuses mainly on molecular studies in pharmacology, with a strong emphasis on chelator drug design, development and effects, as well as metal toxicology.

Prof. Dr. George J. Kontoghiorghes
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chelation therapy
  • metals in medicine
  • free radicals
  • ferroptosis
  • antioxidants
  • anticancer drugs
  • thalassaemia
  • other iron metabolic disorders
  • antimicrobials
  • drug design
  • nutraceuticals
  • metal complexes
  • diagnostic and theranostics

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

32 pages, 8487 KiB  
Review
Towards Clinical Development of Scandium Radioisotope Complexes for Use in Nuclear Medicine: Encouraging Prospects with the Chelator 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid (DOTA) and Its Analogues
by Ioannis Ioannidis, George Lefkaritis, Savvas N. Georgiades, Ioannis Pashalidis and George J. Kontoghiorghes
Int. J. Mol. Sci. 2024, 25(11), 5954; https://doi.org/10.3390/ijms25115954 - 29 May 2024
Viewed by 1687
Abstract
Scandium (Sc) isotopes have recently attracted significant attention in the search for new radionuclides with potential uses in personalized medicine, especially in the treatment of specific cancer patient categories. In particular, Sc-43 and Sc-44, as positron emitters with a satisfactory half-life (3.9 and [...] Read more.
Scandium (Sc) isotopes have recently attracted significant attention in the search for new radionuclides with potential uses in personalized medicine, especially in the treatment of specific cancer patient categories. In particular, Sc-43 and Sc-44, as positron emitters with a satisfactory half-life (3.9 and 4.0 h, respectively), are ideal for cancer diagnosis via Positron Emission Tomography (PET). On the other hand, Sc-47, as an emitter of beta particles and low gamma radiation, may be used as a therapeutic radionuclide, which also allows Single-Photon Emission Computed Tomography (SPECT) imaging. As these scandium isotopes follow the same biological pathway and chemical reactivity, they appear to fit perfectly into the “theranostic pair” concept. A step-by-step description, initiating from the moment of scandium isotope production and leading up to their preclinical and clinical trial applications, is presented. Recent developments related to the nuclear reactions selected and employed to produce the radionuclides Sc-43, Sc-44, and Sc-47, the chemical processing of these isotopes and the main target recovery methods are also included. Furthermore, the radiolabeling of the leading chelator, 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), and its structural analogues with scandium is also discussed and the advantages and disadvantages of scandium complexation are evaluated. Finally, a review of the preclinical studies and clinical trials involving scandium, as well as future challenges for its clinical uses and applications, are presented. Full article
Show Figures

Figure 1

Back to TopTop