MicroRNA/Long Non Coding RNA Networking in Cancer Therapeutics and Diagnostics
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (5 May 2021) | Viewed by 9374
Special Issue Editors
Interests: cancer; miRNAs; nanotechnology; drug delivery; nanosensors; long noncoding RNA; signal transduction; isoprenylation and cancer; aminobisphosphonates; glioblastoma; prostate cancer; hepatocellular cancer; head and neck cancer; Ras; interferons
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Interests: cancer; miRNAs; long noncoding RNA; laryngeal cancer; lung cancer; liquid biopsy; circulating tumor cell; diagnostic biomarkers; signal transduction; cell cycle; PI3K/AKT Pathway; apoptosis; autophagy
Interests: cancer; miRNA; long non-coding RNA; laryngeal cancer; glioblastoma; liquid biopsy; diagnostic biomarkers; anti-inflammatory drugs; cell cycle; apoptosis; autophagy; cancer-related biochemical pathways; drug delivery; small molecule inhibitors; nanotechnology/nanoparticles
Special Issue Information
This Special issue of the International Journal of Molecular Sciences will focus on recent advances in “MicroRNA/long Noncoding RNA Networking in Cancer Therapeutics and Diagnostics”, including new findings concerning miRNAs and long noncoding RNAs as tumor suppressors or oncogenes by regulating one or several cancer hallmarks, including evading cell death, metastasis, drug resistance, and immunological escape; as well as emerging data on miRNA–lncRNA interactions that affect cell death regulation and mechanisms of resistance to therapy. Abnormally expressed miRNAs are strongly associated with cancer development, resistance to chemo-/radiotherapy and anti-cancer immunotherapy, and metastatic potential through targeting a large variety of genes. Current research progress on noncoding (ncRNAs) for clinical and/or potential translational applications, including the identification of novel therapeutic approaches for ncRNA targeting, delivery strategies, will also be appreciated. Circulating ncRNAs are also a useful chance to diagnose a cancer determining its biological aggressiveness features in the field of the so-called “liquid biopsy". New methodological approaches based on the development of nanotechnology-based tools are a new frontier in the determination of circulating ncRNAs in body fluids. Contributions on the definition of ncRNAs as diagnostic and prognostic circulating biomarkers in human cancers and the relative development of cheap and easy-to-use nanosensors will also be well accepted.
The aim of this Special Issue is to present the latest research on the identification of new miRNAs/long noncoding RNA networking as a new opportunity to access better clinical management of malignancies.
Prof. Dr. Michele Caraglia
Dr. Marianna Scrima
Dr. Alessia Maria Cossu
Guest Editors
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Keywords
- miRNAs
- circulating miRNA
- noncoding RNA
- cancer
- epigenetics
- disease biomarkers
- nanosensors
- diagnostics
- prognosticators
- predictive biomarkers of response
- miRNA sponge
- liquid biopsy
- therapeutics
- next-generation sequencing (NGS)
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