Mass Spectrometry Imaging for Drug Pharmacokinetics and Drug Delivery System
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 20 January 2025 | Viewed by 2419
Special Issue Editor
Special Issue Information
Dear Colleagues,
Mass Spectrometry Imaging (MSI) holds great potential in the fields of drug pharmacokinetics and drug delivery systems. It offers the unique advantage of providing spatially resolved information about the distribution and behavior of drugs within biological tissues.
In drug pharmacokinetics, MSI enables for the direct visualization of drugs and their metabolites within tissues, allowing for a comprehensive understanding of their absorption, distribution, metabolism, and excretion. These spatially resolved data aid in determining drug efficacy, optimizing dosage regimens, and advancing personalized medicine approaches.
Additionally, MSI plays a vital role in evaluating drug delivery systems. It offers valuable insights into drug release profiles, targeting efficiency, and potential off-target effects by visualizing drugs' spatial distribution and release of kinetics from various delivery platforms, such as nanoparticles and liposomes. This information assists in the optimization of drug delivery systems for improved therapeutic outcomes and minimized adverse effects.
Various MSI techniques, including MALDI-MSI and DESI-MSI, have been extensively employed in preclinical and clinical studies to investigate drug pharmacokinetics and delivery systems. These techniques offer high spatial resolution, sensitivity, and the ability to analyze a diverse range of compounds. By providing detailed spatial information, they contribute to the development of safer and more effective drug therapies.
Supervised by Prof. Dr. Mitsutoshi Setou and assisted by our Topical Advisory Panel Member Dr. Ariful Islam, this Special Issue aims to gather original research articles and reviews about Mass Spectrometry Imaging for drug pharmacokinetics and drug delivery systems.
Prof. Dr. Mitsutoshi Setou
Guest Editor
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Keywords
- Mass Spectrometry Imaging
- drug pharmacokinetics
- drug delivery systems
- method development
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